Mo nisi itulau ua faaliliuina e le polokalama ma e le saʻo, faamolemole taumafai e siaki le en le gagana Peretania vaaiga mamao mo auiliiliga sili atu.

JW 642

Endocannabinoids e pei o le 2-arachidonoyl glycerol (2-AG) ma le arachidonoyl ethanolamide o lipine e aʻafia ai le ola o loʻo aʻafia i le tele o faʻasologa o synaptic e aofia ai le faʻaagagaina o faʻataʻitaʻiga cannabinoid. O le JW 642 o se inhibitor malosi o le monoacylglycerol lipase (MAGL) o loʻo faʻaalia ai le maualuga ole IC50 o 7.6, 14, ma le 3.7 nM mo le faʻamaina o le MAGL i le kulimi, rat, ma le faiʻai o le faiʻai tagata. JW642is filifilia mo le MAGL, e manaʻomia ai ni maualuga maualuga atu e faʻamalosia ai le gaosiga o le gaʻo gaʻo (IC50s = 31, 14, ma le 20.6 μM mo le kiore, rat, mahuman brain membranes, i le faasologa).

Faamatalaga oloa

 

JW 642 video

 

 


 

I.JW 642 Uiga masani:

 

igoa: JW 642
CAS: 1416133-89-5
Polokalame Molecular: C21H20F6N2O3
Taumaʻa Masele: 462.4
Melt Point:
Teu o le Teuina: i -20 ° C 3 tausaga Malosiaga
Valivali: Paʻepaʻe papaʻe

 


 

II. JW 642 taulaiga

 

1. Igoa:

Suafa Suavai:
4 - [(3-Phenoxyphenyl) methyl] -1-piperazinecarboxylic acid 2,2,2-trifluoro-1- (trifluoromethyl) ethyl ester
Fa'amatalaga:
JW 642;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate

 

2. JW 642 Faʻaaogaina:

I suʻesuʻega suʻesuʻega, mo le teuina o taimi uumi, tatou te fautua atu ia JW 642be o loʻo teuina i -20 ℃. E tatau ona mausali mo le itiiti ifo ma le tasi le tausaga.
Ua tuʻuina atu le JW 642 o se vaifofo i le methyl acetate. Mo le suia o le solvent, faʻafefe ese le methyl acetate i lalo o se vaitafe malulu o le vevela ma vave faʻaopopo le solvent o le filifiliga. O faʻamalosi e pei o le etethanol, DMSO, ma le dimethyl formamide ua faʻamamaina ma se gasite inerua e mafai ona faʻaaogaina. O le solipalaina o le JW 642 i nei solvents e tusa ma le 13,5, ma le 11mg / ml, i le faasologa.
O le JW 642 e faigofie ona solu i totonu o faʻamalosi. Mo le maualuga o le solubility i totonu o le aqueousbuffers, o le vaifofo ethanolic o le JW 642sho e tatau ona faʻamaʻiina i le tochoice o le pa puipui. JW 642 ua i ai se solivaʻa pe tusa o le 0.3 mg / ml i se 1: 2 solution o le ethanol: PBS (pH 7.2) faʻaogaina lenei metotia. Matou te le fautuaina le teuina o le vaifofo vai mo le silia ma le tasi le aso.

 

3.O le a le metotia a JW 642?

DMSO i le 100 mM
Ethanol i 100 mM
Fautuaga ma le Solubility Fautuaga: O nisi fofo e mafai ona faigata ona maua ma mafai ona faʻamalosia e ala i le vave oso, sonication poʻo le mafanafana (i se 45-60 ° C vai vaiinu). O faʻamatalaga e uiga i le faʻamautuina o oloa, aemaise i le fofo, e seasea lipotia ma i le tele o tulaga e mafai ona tatou ofoina atu se taʻiala lautele. O a matou fautuaga e aofia ai: SOLIDS: A o le teuina e pei ona taʻua i luga o le pepa oloa ma o le voli e faʻamaufaʻailogaina, e mafai ona teuina le oloa mo le 6 masina mai le aso o le lisiti. SOLUTIONS: Matou te fautua atu o faʻamaumauga o oloa, pe a uma ona saunia, o loʻo teu faʻaaogaina i totonu o le vateatea -20 ° C poo lalo ma faʻaaogaina i totonu o le 1 masina. O mea uma lava e mafai ona faia ma faʻaaogaina i le aso e tasi.

 

4.E faapefea ona galue JW 642?

O le JW 642 o se inhibitor monoacylglycerol lipase (MAGL) malosi ma filifilia (IC = 3.7 nM). Faʻaalia> 1000-faʻapitoa le faʻavasegaina o le MAGL i luga o le fatty acid amidehydrolase (IC = 20.6 μM). O le monoacylglycerol lipase (MAGL) e maua ai serine hydrolase e nafa ma le hydrolysis o le 2-AG i le arachidonic acid ma le glycerol, ma faamutaina ai lona gaioioga. O aʻafiaga Toxicological atonu e mafua mai i lalo: Methyl Acetate - Faʻamatalaga o le Toxicity: Oral LD50 (rat):> 5,000 mg / kg; Tautala LD50 (lapiti): 3,705 mg / kg; Paʻu LD50 (lapiti):> 5,000 mg / kg; Faʻafouina TCLO (tagata): 15,000 mg / m3; Methyl Acetate - Faʻailoga Faʻamatalaga: Paʻu (lapiti): 500 mg (24h) agamalu; Mata (lapiti): 100 mg (24h) faʻatusa.

 

5.Warning:

I.I le tali atu ma le faʻatinoina

5.1 Reactivity

Stable i lalo o auala fautuaina poʻo femalagaiga.

5.2 Faʻamaumafaʻi faʻamaʻi

Stable i lalo ole tulaga o le teuina.

5.3 Malosiaga o ni faʻafitauli matautia

O aʻafiaga lamatia o le a le tupu i lalo o femalagaiga masani poʻo le teuina. E mafai ona tulai mai se mea e tupu pe a oo i tulaga poʻo mea o loʻo lisi atu i lalo.

5.4 Tulaga e aloese ai mai le vevela, susu.
5.5 Mea e le mafai ona faʻaaoga

Mea malosi malosi / aluma, malosi malosi faʻamaʻi / faʻaitiitiga.

5.6 Mea faʻalavelave faʻaleagaina

I le faʻamafanafana e mafai ona faʻafefe ai vevela vevela. Leai se faʻamatalaga faʻaleagaina.

2. Faʻasalaga ma teuina

5.1 Faʻaeteete mo le faʻaogaina lelei

Faaaoga i totonu o le fale fomaʻi vailaʻau, ma le ea e tuʻuina atu e se ofisa tutoʻatasi. Aloese mai le faʻamalolo, faʻafesoʻotaʻi ma mata, paʻu ma
lavalava. Aloese mai le faia o le pefu ma le aerosols. Faaaoga i totonu o se vaʻa lelei. Taofi ese mai punavai afi. Aloese
faaumiumi pe toe faʻaalia.

5.2 Faʻatonuga mo le malupuipuia saogalemu, e aofia ai soʻo se faʻamalamalamaga.

Teuina i le malulu, vaʻalele lelei. Taofi ese mai le susulu o le la. Tausi siaki kulupu faʻamaufaʻailoga seia sauni mo le faʻaaogaina.
Lagolagosua e teu ai le vevela: Teuina i -20 ° C

5.3 Faʻamatalaga faʻapitoa

Faʻaaoga i totonu o se potu falesuesue faʻailoga pe'ā mafai.

 

6.JW 642 Laupepa Maea:

Min poloaiga 10grams.
O le suʻesuʻega i le aofaʻi masani (I totonu ole 1kg) e mafai ona lafo i 12 itula pe a uma ona totogi.
Mo se faasologa sili atu e mafai ona tuʻuina atu ile 3 aso faigaluega pe a uma le totogiina.

 

7.JW 642 Malosiaga Malamalama Malosi:

Faʻatalanoaina o matou Tagata Faʻatau (CSR) mo auiliiliga, mo lau faʻamatalaga.

 

8.JW 642 Marketing:

Ia saunia i le lumanai.

 

9.Poes JW 642 E I Ai Soʻu Faʻafeagai?

O mea e mafai ona faʻafefe i le mucous membranes ma le pito i luga o le manava; E mafai ona afaina i le maluluina, iniseti, poo le paʻu o paʻu; E mafai ona mafua ai le moe le mafaufau; E mafai ona faʻaleagaina le paʻu poʻo le manava. O le faʻaauau ona faʻaalia e mafai ona mafua ai le mago o le paʻu poʻo le osooso.
Faʻasalaga o faʻataʻitaʻiga / puipuiga patino

9.1 Control faasologa

Vaega o loʻo i ai nofoaga faʻatautaia galuega
E leai ni vailaʻau e iai faʻatapulaʻa faʻatapulaʻa faʻaalia.

9.2 Exposure pulea

Faatonutonuina o pulega faʻainisinia
Faaaoga i totonu o se fale fume pe a talafeagai. Ia mautinoa o faʻataʻitaʻiga uma o loʻo faʻamatalaina i lalo o le 7 o le TAS.
Ia faʻamautinoa o loʻo i ai le falesuesue ma se fale taʻele saogalemu ma le fale e fufulu mata.
Mea e puipuia ai le tagata lava ia

Mata puipui
Faʻaoga tioata saogalemu.
Puipuiga o le paʻu
Faʻaaogā totigilima faʻamalosi faʻamalosi talafeagai (faʻataunuʻuina le manaʻomia o BS EN 374: 2003). O totigilima e tatau ona
asiasia ao le i faaaogaina. Fufuluina ma faʻagogo lima pe'ā maeʻa ona tagofia.
Puipuiga o le tino
Laei ofu talafeagai talafeagai.
Puipuia o le manava
Afai e faʻamaonia e le iloiloga tatau, faʻaaoga se respirator talafeagai.

al i totonu o isi

 


 

III. JW 642 HNMR

 

O matou o Aprepating powder powder, Aprepitant powder for sale, Lafo Faʻatau (170729-80-3) hplc≥98% | AASraw R & D Reagents

 


 

IV. Faʻafefea ona faʻatau JW 642 mai AASraw?

 

1.E faʻafesoʻotaʻi mai i matou i la matou imelisuʻesuʻega, poʻo le skypesui o le au faipisinisi (CSR).
2.E tuʻu mai ia i matou le tele o au fesili ma lau tuatusi.
3.Our CSR o le a tuʻuina atu ia te oe le upusii, taimi o totogi, numera o le suʻega, auala e tuʻuina atu ai ma le aso atofaina e taunuu ai (ETA).
4.Payment na faia ma o oloa o le a auina atu i itula 12 (Mo le faʻasalalauga i totonu ole 10kg).
5.Goods na maua ma tuuina mai ni faʻamatalaga.

 


 

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Auiliiliga atili e uiga i oloa talafeagai,faʻafeiloai e kiliki iinei.


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