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chloride riboside Nicotinamide

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Faamatalaga oloa

Tulaga Autu

Igoa oloa chloride riboside Nicotinamide
Numera CAS 23111-00-4
Faiga Faʻavae Molecular C11H15ClN2O5
Fua Faatatau o le Umi 290.7
Synonyms 23111-00-4

chloride riboside Nicotinamide

Nicotinamide riboside (chloride)

3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride

Nicotinamide ribose chloride

Faʻaaliga Paʻu paʻu
Teuina ma Taulimaina 0 - 4 C mo se taimi puʻupuʻu (aso i vaiaso), poʻo le -20 C mo se taimi umi (masina).

 

Nicotinamide riboside chloride Faʻamatalaga

O le Nicotinamide Riboside Chloride (NIAGEN) o le chloride salt form o le nicotinamide riboside (NR) .NR o se ituaiga fou pyridine-nucleoside o le vaitamini B3 o loʻo avea ma faʻamuamua i le nicotinamide adenine dinucleotide (NAD) poʻo le NAD +. (GRAS) i le Iunaite Setete mo le faʻaaogaina i oloa taumafa. Nicotinamide riboside chloride o se foliga tioata o le Nicotinamide riboside (NR) chloride. O le Nicotinamide riboside chloride e faʻaopopoina ai le maualuga o le NAD [+] ma faʻagaoioia ai le SIRT1 ma le SIRT3, faʻaiʻu ai i le faʻalauteleina o le oxidative metabolism ma le puipuiga mai le maualuga o gaʻo o le diet-induced Nicotinamide riboside chloride efuefu o loʻo faʻaaogaina i meaʻai faʻaopopo.

 

Nicotinamide riboside chloride Auala o gaioiga

Nicotinamide Riboside Chloride (NIAGEN) o le chloride masima ituaiga o nikotinamide riboside (NR). NR o se pyridine-nucleoside ituaiga o vaitamini B3 o loʻo avea ma faʻamuamua i le nikotinamide adenine dinucleotide poʻo le NAD +. NR poloka faʻaleagaina o taotoga motusia dorsal aʻa ganglion neurons ex vivo ma puipuia faasaga i le pisapisaia-faʻaosofia le faʻalogo i le ola isumu. Nicotinamide riboside efuefu puipuia maso, neural ma melanocyte poʻa sela senescence. O le faʻateleina o muscular regeneration i isumu na maitauina ina ua maeʻa togafitiga ma le nikotinamide riboside, ma mafua ai le masalosalo atonu e faʻaleleia ai le toe faʻafouina o totoga e pei o le ate, fatugaʻo, ma le fatu. O le Nicotinamide riboside e faʻaititia ai foi le toto suka ma le gaʻo ile ate ile prediabetic ma le ituaiga 2 diabetic models aʻo puipuia le atinaʻeina ole neuropathy peripheral suka. Faʻaaliga: Nicotinamide Riboside chloride o le α / β palu.

 

Nicotinamide riboside chloride Talosaga

O le Nicotinamide riboside chloride efuefu ua lesitalaina ma le numera CAS 23111‐00‐4 ma le EC numera 807‐820‐5. O lona igoa IUPAC o le 1 - [(2R, 3R, 4S, 5R) ‐3,4 ‐ dihydroxy ‐ 5‐ (hydroxymethyl) oxolan ‐ 2 ‐ yl] pyridin ‐ 1 ‐ ium ‐ 3 ‐ carboxamide; chloride. O le molemula fua o le nikotinamide riboside chloride o C11H15N2O5Cl, ma lona mamafa mole mole 290.7 g / mol. O le Nicotinamide Riboside Chloride (NIAGEN) o le chloride salt form o le nicotinamide riboside (NR) .NR o se ituaiga fou pyridine-nucleoside o le vaitamini B3 o loʻo avea ma faʻamuamua i le nicotinamide adenine dinucleotide (NAD) poʻo le NAD +. E manaʻomia e le tino le NAD + e galue masani ai. Laʻititi maualalo o le NAD + e ono mafua ai faʻafitauli tau soifua maloloina. Aveina o le nikotinamide riboside e mafai ona fesoasoani e faʻatupuina nei maualalo NAD + tulaga.

 

faamanuiaga o chloride riboside Nicotinamide

O le Nicotinamide riboside Chloride, o se faʻaaliga tautala i le NAD + muamua, e faʻateleina ai le maualuga o le NAD + ma faʻagaoioia ai le SIRT1 ma le SIRT3. Nicotinamide riboside Chloride powder is a source of vitamini B3 (niacin) ma faʻaaoga le Nicotinamide riboside Chloride efuefu e mafai ona faʻaleleia ai le oxidative metabolism, puipuiga mai le maualuga gaʻo o le diet-induced metabolic abnormalities. O le Nicotinamide riboside Chloride e faʻaititia ai le faʻaletonu o le mafaufau i se faʻamaʻi o le isumu transgenic o le faʻamaʻi o le Alzheimer.

 

Tusitaiala

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[2] Bogan KL, Brenner C. Nicotinic acid, nikotinamide, ma le nikotinamide riboside: o se faʻataʻitaʻiga molimoli o le NAD + vailaʻau muamua i meaʻai a le tagata. Annu Rev Nutr. 2008; 28: 115-30. fai: 10.1146 / annurev.nutr.28.061807.155443. Iloiloga PubMed PMID: 18429699.

[3] Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation o se cell-intrinsic, evolusione avetaʻavale mo le teuina o gaʻo: vailaʻau ma metabolic mafuaaga o le acetyl-lysine suiga. Crit Rev Biochem Mol Biol. 2013 Nov-Tes; 48 (6): 561-74. faia: 10.3109 / 10409238.2013.838204. Iloiloga PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.

[4] Yang Y, Sauve AA. NAD (+) metabolism: Bioenergetics, faʻailo ma togafiti mo togafitiga. Biochim Biophys Acta. 2016 Tes; 1864 (12): 1787-1800. fai: 10.1016 / j.bbapap.2016.06.014. Iloiloga PubMed PMID: 27374990.

[5] Sauve AA. NAD + ma vitamini B3: mai metabolism i togafitiga. J Pharmacol Exp Ther. 2008 Mati; 324 (3): 883-93. faia: 10.1124 / jpet.107.120758. Iloiloga PubMed PMID: 18165311.

[6] Kato M, Lin SJ. Faʻatonutonuina o le NAD + metabolism, faʻailoaina ma faʻavasegaina i le fefete Saccharomyces cerevisiae. DNA toe faʻaleleia (Amst). 2014 Nov; 23: 49-58. fai: 10.1016 / j.dnarep.2014.07.009. Iloiloga PubMed PMID: 25096760; PubMed Central PMCID: PMC4254062.

[7] Cantó C, et al. O le NAD (+) o loʻo amataina i le nikotinamide riboside e faʻalauteleina ai le gaʻo o le oxidative metabolism ma puipuia ai le maualuga o le gaʻo o meaʻai na mafua ai le lapoʻa. Cellab Metab. 2012 Jun 6; 15 (6): 838-47.

[8] Bing Gong, et al. Nicotinamide Riboside Faʻafouina le Faʻalauiloaina e ala i le Faʻaleleia o Proliferator-Activated Receptor-γ Coactivator 1α Faʻatonutonu β-Secretase 1 Faʻaleagaina ma Mitochondrial Gene Expression i Alzheimer's Mouse Model. Neurobiol matua. 2013 Iuni; 34 (6): 1581-8.

[9] Collin D Heer, et al. O le Coronavirus ma le PARP Expression e faʻamamaina le NAD Metabolome: O se Vaega e mafai ona faʻatinoina le puipuia o le Innate. bioRxiv. 2020 Ape 30; 2020.04.17.047480.