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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

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SKU: 681136-29-8. Category:

AASraw faʻatasi ma le faʻasologa ma le gaosiga gafatia mai le gram i le faʻatonuga o le N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide powder (CAS 681136-29-8), i lalo o tulafono a le CGMP ma le siakiina lelei o le tino.

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video


N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters

igoa: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Mama: ≥99% (HPLC)
Fa'amatalaga: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Polokalame Molecular: C19H19N5OS
Taumaʻa Masele: 365.459
Motuga faʻamafanafana: 240.48
Taumafa suamalie: 559.69 ° C i 760 mmHg
Uiga: ~ 1.3 g / cm3
Teu o le Teuina: Teu i le + 4 ° C
Solubility: DMSO: ≥28mg / mL
Faʻamatalaga faʻasoa: n20D 1.68
Valivali: O se maa malosi
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChI Key: BHBOSTKQCZEAJM-UHFFFAOYSA-N


N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Faaaogaina o le eletise i le lio

igoa

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid pefu, JNJ 166101 Powder

E faapefea ona galue le N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Malosiaga o le Malosiaga

O le FAAH na faʻasolosolo i le JNJ-1661010 o loʻo fautuaina mai ai le faʻagasolo malie o le fegalegaleaiga i le va o le JNJ1661010 ma le 'auʻaunaga gaosi, lea e faatelevaveina i le maualuga o le vevela. O le JNJ-1661010 o se inhibitor substrate e faʻalagolago i le masini e pei ona suʻesuʻeina e le LC-ESI-MS. O le JNJ-1661010 faʻatasi ma le phenylthiadiazole i le vaituloto mamanu ma le phenylurea i totonu o le tagavai hydrophilic o FAAH, JNJ-1661010 (20 mg / kg ip) e faʻalavelave ai le FAAH e tusa ma le 85% mo le 4 h i le maea ai o le dosing, faʻateleina le lipid ethanolamides i le mafaufau o le rat. Ole fua ole JNJ-1661010-faʻaaogaina ma le faʻavaivai le faʻaaogaina o le faʻaaogaina o le faʻaaogaina o se mea e sili ile aoga ile 90% i le 30 min e tuʻuina i le Mice Thermal Result (MTI) ma le rat. JNJ-1661010 (20 mg / kg) faʻaaogaina le faʻaaogaina e le 60.8% i le 30 min i le tui o le tui o le nerve liʻa. O le JNJ-1661010 (50 mg / kg ip) o loʻo faʻaalia ai se atinaʻe taua ole hyperraliaia i le 30 min e tuʻuina i totonu o le rat carrageenan faʻataʻitaʻiga o le tiga o le inflammatory.
Rats dosed with JNJ-1661010 (20 mg / kg ip) ei ai le plasma Cmax o 26.9 μM i le Tmax o le 0.75 h ma le Cmax i le mafaufau o le 6.04 μM i le Tmax o le 2 h. JNJ-1661010 (20 mg / kg ip) faʻalavelaveina le mafaufau FAAH ma siitia le maualuga o le AEA i le faiʻai i le rat.

Isi faatonuga

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder

Min poloaiga 10grams.
O le suʻesuʻega i le aofaʻi masani (I totonu ole 1kg) e mafai ona lafo i 12 itula pe a uma ona totogi.
Mo le faasologa sili (I totonu 1kg) e mafai ona auina atu ile 3 workingdays pe a uma le totogiina.

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder Marketing

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