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Amin-Aminobutyric acid (GABA)

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Kipea e ave e le gutu mo le faʻamamaina o le popole, faʻaleleia o lagona, faʻaititia o faʻailoga o le premenstrual syndrome (PMS), ma le togafitia o faʻalogo deficit-hyperactivity faʻaletonu (ADHD). E faʻaaogaina foi mo le faʻamalosia o le tuputupu aʻe o maso maso, susunuina gaʻo, faʻamautuina le toto, ma faʻamalolo tiga.

Faamatalaga oloa

Tulaga Autu

Igoa oloa Amin-Aminobutyric acid (GABA)
Numera CAS 56-12-2
Faiga Faʻavae Molecular C4H9NO2
Fua Faatatau o le Umi 103.12
Synonyms 4-aminobutyric acid

4-Aminobutanoic acid

gamma-aminobutyric acid

Kipea

56-12-2

Faʻaaliga Paʻu paʻu
Teuina ma Taulimaina Faʻamago, pogisa ma 0 - 4 C mo se taimi puʻupuʻu, pe -20 C mo se taimi umi.

 

Amin-Aminobutyric acid (GABA)faʻamatalaga

O le amin-aminobutyric acid, poʻo le gamma-Aminobutyric acid, poʻo le GABA, o le faʻauluuluga lea o le neurotransmitter i le faʻatupulaia o le tino o tina. O lana matafaioi autu o le faʻaititia o le neuronal excitability i totonu o le neula.

O le GABA e faʻatau atu e fai ma faʻaopopoga o meaʻai i le tele o atunuʻu. E masani ona manatu o le GABA tele (o lona uiga o le faʻaopoopoga) e le sopoʻia le papala o le toto-faiʻai, peitaʻi o faʻamatalaga na maua mai i suʻesuʻega o loʻo iai nei e taʻu mai ai e ono mafai.

 

Amin-Aminobutyric acid (GABA) Faiga o Gaioiga

Fualaʻau e avea ma allosteric modulator o GABA talimalo (ua faʻaigoaina o le GABA analogues poʻo le GABAergic vailaʻau), pe faʻateleina le avanoa avanoa o le GABA, e masani lava ona malolo, teteʻe i le popole, ma aneti-faʻafitauli aafiaga. Tele o mea o loʻo i lalo ua iloa e mafua ai le anterograde amnesia ma retrograde amnesia.

I se tulaga lautele, o le GABA e le sopoia le toto-faiʻai papupuni, e ui o ni vaega o le faiʻai e leai se aoga o le toto-faiʻai paʻu, pei o le periventricular nucleus, e mafai ona oʻo i ai vailaʻau e pei o le faʻaaogaina o le GABA. Le itiiti ifo ma le tasi suʻesuʻega fautua mai ai o le tautala tuʻuina GABA faʻateleina le aofaʻi o tagata tuputupu ae homone (HGH). GABA tuʻua tui i le faiʻai ua lipotia mai i ai uma stimulate ma taofiofia aafiaga i luga o le gaosia o le tuputupu ae homone, faalagolago i le tino o le tagata lava ia. O nisi vailaʻau-faʻatamaonia o le GABA (ex.

GABA faʻalauteleina le catabolism o serotonin i le N-acetylserotonin (o le muamua o le melatonin) i isumu. O lea e masalomia o le GABA o loʻo aʻafia i le tuʻufaʻatasia o le melatonin ma ono aʻafia ai le faʻatonutonuina o aafiaga i le moe ma le toe fanaina.

 

Amin-Aminobutyric acid (GABA) talosaga

Gamma-Aminobutyric Acid o se natura tupu neurotransmitter ma tutotonu neura (CNS) taofiofia gaioiga. Gamma-aminobutyric acid (GABA), liua mai le autu faʻamalosia neurotransmitter glutamate i le faiʻai, faia se sao i le faʻatonutonuina o le fiafia o le neuronal e ala i le fusifusia i ona taliaina, GABA-A ma le GABA-B, ma mafua ai le mafuaʻaga o le auala ion, hyperpolarization ma mulimuli ane taofia o le neurotransmission.

Gamma-aminobutyric acid o se gamma-amino acid o le butanoic acid ma le sui o le amino o loʻo i C-4. E i ai lona matafaioi o se mole faʻailo, o le tagata metabolite, o le Saccharomyces cerevisiae metabolite ma se neurotransmitter. O le gamma-amino acid ma le monocarboxylic acid. E mafua mai i le butyric acid. O se conjugate acid o se gamma-aminobutyrate. O se tautomer o le gamma-aminobutyric acid zwitterion.

 

Faʻamanuiaga o le γ-Aminobutyric acid (GABA)

Kipea e ave e le gutu mo le faʻamamaina o le popole, faʻaleleia o lagona, faʻaititia o faʻailoga o le premenstrual syndrome (PMS), ma le togafitia o faʻalogo deficit-hyperactivity faʻaletonu (ADHD). E faʻaaogaina foi mo le faʻamalosia o le tuputupu aʻe o maso maso, susunuina gaʻo, faʻamautuina le toto, ma faʻamalolo tiga.

 

Tusitaiala

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2, Campagna JA, Miller KW, Forman SA (Me 2003). "Faʻavaeina o gaioiga o manava manava faʻasoesa". N. Engl J. Med. 348 (21): 2110–24. faia: 10.1056 / NEJMra021261. PMID 12761368.

3, Müller EE, Locatelli V, Cocchi D (Aperila 1999). "Neuroendocrine faʻatonutonuina o le tuputupu ae o le homone faʻalilolilo". Physiol. Faʻaaliga 79 (2): 511-607. faia: 10.1152 / physrev.1999.79.2.511. PMID 10221989.

4, Powers ME, Yarrow JF, McCoy SC, Borst SE (Ianuari 2008). "O le tuputupu ae o le homone isoform tali i le GABA taumafaina i le malologa ma pe a maeʻa faamalositino". Faʻafomaʻi ma Saienisi i Taʻaloga ma Faʻamalositino. 40 (1): 104–10. faia: 10.1249 / mss.0b013e318158b518. PMID 18091016.

5, Balemans MG, Mans D, Smith I, Van Benthem J (1983). "O le aʻafiaga o le GABA i le tuʻufaʻatasia o le N-acetylserotonin, melatonin, O-acetyl-5-hydroxytr Egyptophol ma O-acetyl-5-methoxytr Egyptophol i le pine pine gland male male Wistar rat". Gaosia, Fafagaina, Atinaeina. 23 (1): 151–60. faia: 10.1051 / rnd: 19830114. PMID 6844712.

6, Sato S, Yinc C, Teramoto A, Sakuma Y, Kato M (2008). "Feusuaiga dimorphic fesuiaʻiga o GABA (A) taliaina talo e ala i le melatonin i isumu gonadotropin-faʻasaʻolotoina neoneoneoneoneone". J Physiol Sci. 58 (5): 317–322. fai: 10.2170 / physiolsci.rp006208. PMID 18834560.

7, Kuriyama K, Sze PY (Ianuari 1971). "Toto-faiʻai pa puipui i le H3-γ-aminobutyric acid i masani ma amino oxyacetic acid-togafitia manu". Neuropharmacology. 10 (1): 103–108. faia: 10.1016 / 0028-3908 (71) 90013-X. PMID 5569303.

8, Foster AC, Kemp JA (Fepuari 2006). "Glutamate- ma GABA-faʻavae CNS togafitiga". Curr Opin Pharmacol. 6 (1): 7–17. faia: 10.1016 / j.coph.2005.11.005. PMID 16377242.