Afatinib paula (439081-18-2) - Tagata gaosi oloa gaosi oloa
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Afatinib

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Afatinib paula, faʻatau atu i lalo o le igoa igoa Gilotrif faʻatasi ai ma isi, o se vailaʻau na faʻaaogaina e togafitia ai le laiti-sela sela kanesa kanesa (NSCLC) .E ona i le tyrosine kinase taofiofia aiga o vailaʻau. E ave e le gutu.

Faamatalaga oloa

Tulaga Autu

Igoa oloa Afatinib efuefu
Numera CAS 439081-18-2
Faiga Faʻavae Molecular C24H25ClFN5O3
Fua Faatatau o le Umi 485.9
Synonyms Efuefu Afatinib;

439081-18-2;

850140-72-6;

BIBW2992;

Tovok.

Faʻaaliga Paʻu paʻu paepae paʻepaʻe
Teuina ma Taulimaina Teu ia i le vevela potu ma alu ese mai le sili atu vevela ma susu.

 

Afatinib Powder Faʻamatalaga

Afatinib paula, faʻatau atu i lalo o le igoa igoa Gilotrif faʻatasi ai ma isi, o se vailaʻau na faʻaaogaina e togafitia ai le laiti-sela sela kanesa kanesa (NSCLC) .E ona i le tyrosine kinase taofiofia aiga o vailaʻau. E ave e le gutu.

Afatinib efuefu e masani ona faʻaaogaina e togafitia ai mataupu o le NSCLC o loʻo taofia fesuiaʻiga i le epidermal tuputupu aʻe mea faʻatonu (EGFR) gene.

 

Afatinib Powder Faiga o Gaioiga

E pei o le lapatinib ma le neratinib, o le afatinib pauta o le polotini kinase e taofia ai foi e le mafai ona toe taofia le faʻatupuina o le toto o tagata i luga o le tino (2) ma le faʻaolaola o mea tutupu (EGFR). Afatinib efuefu e le gata faʻagaoioia faasaga i EGFR fesuiaʻiga fuafuaina e le augatupulaga muamua tyrosine-kinase iniseti (TKI) pei erlotinib po gefitinib, ae faʻapea foi faasaga i laʻititi masani suiga e teteʻe atu i nei vailaʻau. Ae ui i lea, e le o faʻagaioia faʻasaga i le T2M suiga e masani ona manaʻomia ai le lona tolu o augatupulaga vailaʻau pei o le osimertinib. Ona o lona faʻaopopo gaioiga faʻasaga ia Her790, o loʻo suʻesuʻeina ai mo le kanesa o le susu faʻapea foi ma isi EGFR ma Her2 driven cancer.

 

Afatinib Powder Application

Afatinib paula ua mauaina faʻatonuga faʻatonutonuina mo le faʻaaogaina o se togafitiga mo le le-laʻititi sela kanesa kanesa, e ui lava o loʻo iai faʻamaonia molimau e lagolagoina lona faʻaaogaina i isi kanesa e pei o le kanesa kanesa.

 

Afatinib Powder Itu Aafiaga & Lapataiga

Masani tele (> 10% taimi masani)

▪ Tatala (> 90%)

▪ Fuafua / dermatitis fuafua i fuafua

▪ Stomatitis

▪ Paronychia

▪ Faʻaitiitia le fiaai

▪ Faalu le isu

▪ Ita

▪ Paʻu mago

 

Masani (1-10% taimi)

▪ Faʻamamaina, Suia tofo, mago mata

▪ Cystitis, Cheilitis, Fiva

▪ Ose isu / ua isumu

▪ Lalo maualalo le potassium i le toto

▪ Faʻafitauli o le mafaufau

▪ Faateleina ALT

▪ Faateleina AST

▪ Faamaʻi vae-vae

▪ Maʻi maso

▪ Faʻaletonu fatugaʻo ma / pe ua le manuia

 

Le masani ai (0.1-1% taimi)

▪ Keratitis

▪ Faʻamaʻi pipisi i totonu ole mama

 

Tusitaiala

[1] "Gilotrif (afatinib paʻu) laupapa, ata ufiufi". Aso Taʻitasi Boehringer Ingelheim Faletalavai, Inc. 18 Oketopa 2019. Toe aumai 4 Novema 2020.

[2] Spreitzer H (13 Me 2008). "Neue Wirkstoffe - Tovok". Österreichische Apothekerzeitung (i le Siamani) (10/2008): 498

[3] Minkovsky N, Berezov A (Tesema 2008). "BIBW-2992, o le lua receptor tyrosine kinase taofiofia mo le togafitia o mautu tuma". Manatu o loʻo iai nei ile Sailiga o Fualaʻau. 9 (12): 1336–46. PMID 19037840.

[4] "Afatinib Powder". US Taumafa ma Vailaau Faafoeina. 12 Iulai 2013. [mate soʻoga] [5] "Giotrif Afatinib Powder (as afatinib dimaleate)" (PDF). TGA Tautua Tautua. Boehringer Ingelheim Pty Limited. 7 Novema 2013. Toe aumai 28 Ianuari 2014.

[6] Vavalà T (2017). "Mataʻupu o le afatinib paʻu i le togafitia o le mama o le squamous cell carcinoma". Fomaʻi Fomaʻi. 9: 147–157. faia: 10.2147 / CPAA.S112715. PMC 5709991. PMID 29225480.