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Alfaxalone

fua faatatau: Category:

Alfaxalone o se neuroactive vailaʻau mole mole ma meatotino o se lautele vailaʻau. O le Alfaxalone o loʻo faʻamatalaina vailaʻau o le 3-α-hydroxy-5-α-Hamil-11, 20-dione, ma e 332.5 le mamafa o le molelaa…

Faamatalaga oloa

Tulaga Autu

Igoa oloa Alfaxalone
Numera CAS 23930-19-0
Faiga Faʻavae Molecular C21H32O3
Fua Faatatau o le Umi 332.48
Synonyms Alphaxalone;

Alfaxalone;

23930-19-0;

5alpha-Pregnan-3alpha-ol-11,20-dione;

Alfaxalonum.

Faʻaaliga Paʻu paʻu
Teuina ma Taulimaina Faleoloa i potu faʻatonutonu vevela -20 ° C

 

Faʻamatalaga Alfaxalone

Alfaxalone o se neuroactive vailaʻau mole mole ma meatotino o se lautele vailaʻau. O le Alfaxalone o loʻo faʻamatalaina i le kemisi o le 3-α-hydroxy-5-α-hamiline-11, 20-dione, ma e iai le mamafa o le tino 332.5. O le muamua auala mo le gaioiga faʻagalue o alfaxalone o le faʻatulagaina o le neuronal cell membrane chloride ion felauaiga, faʻamalosia e le fusifusia o alfaxalone i le GABAA (gamma-aminobutyric acid) sela luga taliaina.

 

Alfaxalone Faʻatinoina o gaioiga

Alfaxalone e maua ai le le malamalama e ala i le faʻatinoina o le gamma aminobutyric acid subtype A (GABAA) faʻaola i totonu o le ogatotonu o le tino (CNS). O nei talipupuni o ionotropic ligand-gated auala, ma GABA o latou endogenous ligand. O le GABA o le autu faʻatamaʻiina le neurotransmitter i le CNS. A maeʻa ona faʻagaoioia le receptor, ona tatalaina lea o le auala ma faʻamalosia le faʻamalosiina o le chloride i totonu o le sela, ma mafua ai loa le faʻatuputeleina o le membrane postynaptic. I maualalo faʻasologa, alfaxalone mautinoa fesuiaʻi taimi nei chloride ala i le auala chloride; ae i maualuga maualuga concentrations, e galue o se GABA agonist, i le tutusa auala e pei o barbiturates. O le iʻuga o le loloto o le faʻamalieina poʻo le faʻatumuina o vai faagase, faʻalagolago i le fualaʻau ma le ala o le faʻatautaiga.

 

Talosaga Alfaxalone

Alfaxalone, lea e taʻua o le alphaxolone poʻo le alphaxalone ma faʻaaogaina i lalo ole igoa fefaʻatauaʻi Alfaxan, o se neuroactive steroid ma lautele vailaʻau faʻatau vailaʻau faʻaaogaina i maile ma pusi. E mafai ona faʻaaogaina o se sui soʻosoʻo poʻo mo se vailaʻau lautele.

 

Alfaxalone Lelei & Le lelei

  • lelei:

O le Alfaxalone e mafua ai sina suiga i le faʻamaʻiina o le fatu poʻo le toto maualuga pe a faʻataʻitaʻia togafitiga faʻapitoa i tui maloloina. Alfaxalone e i ai le maualuga togafitiga faʻasino igoa, e puupuu galue, ma noncumulative. Nei uiga faia alfaxalone fetaui lelei mo le faʻaaogaina o se induction sooupu pe mo le tuʻuina atu iniseti tui.

Alfaxalone mafai foi ona faʻatautaia intramuscularly, o lea e mafai ai ona faʻaaogaina e faʻamalie ai uncooperative tagata mamaʻi. A faʻaoga le alfaxalone e faʻamalosi ai le tagata maʻi o le vailaʻau o le 1-3mg / kg IM ma e masani ona tuʻufaʻatasia ma se opioid mo se faʻamaliega lelei.

A faʻaoga le alfaxalone mo caesarean e mataala ma ola lelei tamai maile ma faʻaleleia atili togi AGPAR faʻatusatusa i le propofol.

 

  • tulaga le lelei:

Alfaxalone mafua ai fualaʻau faʻamoemoe manava faʻafitauli, ma apnea ono tupu pe a maeʻa vave IV tui. Sauni e sulugia, tuʻuina atu le okesene lagolago, ma faʻamalosi peʻa faʻaaoga le alfaxalone mo le faʻatosina poʻo le faʻamalieina.

O le tele o le faʻatautaiga o le alfaxalone e mafai ona mafua ai le faʻalagolago i le fualaʻau i le lotovaivai faʻanoanoaga, ma le taua paʻu uma i le faʻamaʻi o fatu ma le toto. O le fualaʻau o le alfaxalone e tatau ona titrated ma le faʻaeteete i tagata mamaʻi ua faʻaititia le fatuvave faʻasao pe ua hemodynamically le mautonu.

Alfaxalone e le maua ai se analgesia, o le mea lea e tatau ai ona faʻaaogaina faʻatasi ma se talafeagai opioid mo tiga taualumaga.

A faʻatautaia le alfaxalone i totonu ole toto e mafai ona lapoʻa le tui, ono mafua ai le tiga ile tui. Ole lapoʻa tele e mafai foi ona avea pulega faʻafitauli peʻa iai se faʻatapulaʻa faʻamalama mo tui ona o le onosai uiga. Alfaxalone pulega mafai ono iʻu ai i le le lelei toe faʻaleleia foliga mai e eseese tikeri o foe, leo, ma / poʻo myoclonus.

 

Tusitaiala

[1] Whittem T, Pasloske KS, Heit MV et al. (2008) O vailaʻau ma vailaʻau mo vailaʻau o alfaxalone i pusi peʻa maeʻa le toʻatasi ma tele faʻataʻitaʻiga o alfaxan ile falemaʻi ma tofo supraclinical. J Vet Pharmacol Ther 31 (6), 571-579.

[2] Ferre PJ, Pasloske K, Whittem T et al. (2006) Plasma pharmokinetics o alfaxalone i maile ina ua maeʻa le gaʻo o le Alfaxan-CD. Vet Anaesth Analg 33, 229-236.

[3] Muir W, Lerche P, Wiese A et al. (2009) O le cardiorespiratory ma vai faagase aafiaga o falemaʻi ma supraclinical inumaga o alfaxalone i pusi. Vet Anaesth Analg 36, 42-54.

[4] Clarke KW, Trim CM, Hall LW, eds. (2014). "Mataupu 15: Anesthesia o le maile". Vailaʻau Vailaʻau (11th ed.). Oxford: WB Saunders. i. 135–153.

[5] Varga M (2014). "Mataupu 4: Anesthesia ma Analgesia". Tusitusiga o Rabbit Medicine (2nd ed.). Butterworth-Heinemann. i. 178–202.

[6] Nieuwendijk H (Mati 2011). "Alfaxalone". Vailaʻau Vaʻaia Vaʻaia & Vaʻaia Vaega Fesoasoani. Toe aumai Iulai 14, 2017.

[7] Zeltzman P (Novema 17, 2014). "Aisea Faʻafoeina Alfaxalone Manaʻomia Se Iti o Aʻoga". Tala Fou Faʻataʻi manu Toe aumai Iulai 14, 2017.