AZD-9291 paʻu (1421373-65-0) - Fale gaosi oloa
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FA-9291

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AZD-9291 efuefu o se epidermal tuputupu aʻe mea taliaina (EGFR) tyrosine kinase iniseti (TKI) e fusifusia i nisi mutant ituaiga o EGFR (T790M, L858R, ma exon 19 soloia) e muamua i non-laiti sela sela kanesa (NSCLC) tumors mulimuli togafitiga ma laina muamua EGFR-TKIs.

Faamatalaga oloa

Tulaga Autu

Igoa oloa AZD-9291 paʻu
Numera CAS 1421373-65-0
Faiga Faʻavae Molecular C28H33N7O2
Fua Faatatau o le Umi 499.6
Synonyms 1421373-65-0;

osimertinib;

Mereletinib;

AZD9291;

N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide.

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Teuina ma Taulimaina Faleoloa i le potu vevela i le va o le 20 ° C-25 ° C

 

AZD-9291 Powder Faʻamatalaga

AZD-9291 paʻu o se taulaʻi faʻataʻitaʻiga togafitiga e faʻatatau i le suia o le tupuola o le epidermal tuputupu aʻe (EGFR) T790M i totonu o le kanesa sela.

Ole vaega ole EGFR e taua tele ile taua ma sela ole kanesa. O lenei kenera e mafua ai le gaosiaina o le EGFR protein. O lenei polotini e masani lava o se vaega o le filifili o molelaʻae faʻafefeina se faʻailo e taʻu ai sela pe faʻafefea ona tupu ma vaelua. O se suiga i le EGFR gene (taʻua o le fesuiaʻiga) mafai ona suia le auala e galue ai le EGFR protein. Nai lo le faʻatali mo lona taimi e faʻailo ai se sela e vaelua pe tupu, o le EGFR protein e le mafai ona taofiofia ma faʻailo i taimi uma, o le le faʻatonutonuina o le faʻailo EGFR e ono unaʻia ai le le faʻatonutonuina o le tuputupu aʻe o sela kanesa. AZD-9291 efuefu faʻatulagaina filifili mutant ituaiga o EGFR, aofia ai t790M, L858R ma exon 19-soloia. AZD-9291 efuefu e filifilia mo le faʻalauteleina o fesuiaiga ma le T790M teteʻeina fesuiaʻiga, o le sili ona taatele auala o teteʻe atu i EGFR tyrosine kinase inhibitors.

 

AZD-9291 Powder Faʻavae o Gaioiga

AZD-9291 efuefu o se epidermal tuputupu aʻe mea taliaina (EGFR) tyrosine kinase iniseti (TKI) e fusifusia i nisi mutant ituaiga o EGFR (T790M, L858R, ma exon 19 soloia) e muamua i non-laiti sela sela kanesa (NSCLC) tumors mulimuli togafitiga ma laina muamua EGFR-TKIs. I le avea ai o le isi augatupulaga lona tolu tyrosine kinase taofiofia, AZD-9291 paʻu e faʻapitoa mo le leoleo-faitotoʻa T790M suiga e faʻateleina ATP fusia gaioiga i le EGFR ma mafua ai le le lelei vaʻai faʻaiʻu mo tuai-tulaga faamai. E le gata i lea, o le AZD-9291 paʻu (osimertinib) na faʻaalia e faʻasaoina le ituaiga vao o le EGFR i le taimi o togafitiga, ma faʻaititia ai le le faʻapitoa ona fusifusia ma faʻatapulaʻa ai le oʻona.

 

AZD-9291 Powder Talosaga

O le AZD-9291 paʻu o se vailaʻau talavai mo le kanesa laiti ninii sela (NSCLC) ua sosolo atu i isi vaega o le tino (metastatic). AZD9291 o loʻo faʻaaogaina:

▪ E fai ma au togafitiga muamua pe a fai e maua e tagata tuma le siama ole faʻalaʻitiiti (EGFR)

▪ A iai sau ituaiga kenera o le EGFR ma na togafitia muamua ile vailaʻau ole EGFR tyrosine kinase inhibitor (TKI) e le ola pe ua le toe aoga.

 

AZD-9291 Malosiaga Itu Itu & Lapataiga

AZD-9291 paʻu ono mafua ai aʻafiaga matuia, aofia ai:

Problems faʻafitauli o le mama. O le pauta AZD-9291 e ono mafua ai faʻafitauli o le māmā e ono iʻu ai i le oti. Faʻailoga atonu e tutusa ma faʻailoga mai kanesa kanesa. Taʻu vave i lau fomaʻi pe a iai sau faʻailoga fou pe leaga foi o le mama, e aofia ai ma le faʻalavelave manava, manava manava, tale, poʻo le fiva

Problems faʻafitauli o le fatu, e aofia ai ma le fatu fatu. AZD-9291 paʻu ono mafua ai faʻafitauli i le fatu e ono mafua ai le oti. E tatau i lau fomaʻi ona siaki lau fatu gaioiga ae e te leʻi amata inuina le pauta AZD-9291 ma i le taimi o togafitiga pe a manaʻomia. Taʻu vave i lau fomaʻi pe a iai ni faʻailoga ma faʻailoga o se faʻafitauli i le fatu: lagona e pei o lou fatu ua tata pe tamoʻe, puupuu le manava, fulafula o ou tapuvae ma vae, lagona mumu

▲ faʻafitauli o mata. AZD-9291 paʻu ono mafua ai faʻafitauli tau mata. Taʻu vave i lau fomaʻi pe a fai oe ma faʻailoga o mata faʻafitauli e ono aofia ai mata vai, malamalama lelei i le malamalama, tiga mata, mumu mata, poʻo suiga vaʻai. Atonu e auina atu oe e lau fomaʻi e vaai se fomaʻi faʻapitoa (ophthalmologist) pe a fai e iai ou faʻafitauli tau mata i le pauta AZD-9291.

▲ paʻu faʻafitauli. AZD-9291 paʻu ono mafua ai faʻafitauli i le paʻu. Taʻu vave i lau fomaʻi pe a fai e tutupu ni faʻamaʻai (paʻu e pei o ni mama), ogaoga le paʻu poʻo le paʻu o le paʻu.

 

O aʻafiaga masani a AZD-9291 paʻu o le:

▪ manava tata

▪ mageso

▪ paʻu matutu

▪ suiga i ou fao, e aofia ai: mumu, agamalu, tiga, fulafula, mageso, tuuʻese mai fao, ma le masaa o fao

▪ papala gutu

▪ lelava

▪ faaititia le fiaai

E leʻo nei uma ni aʻafiaga ono o le pauta AZD-9291. Mo nisi faʻamatalaga, fesili i lau fomaʻi poʻo le faletalavai.

Valaʻau lau fomaʻi mo fautuaga faʻafomaʻi e uiga i aʻafiaga. E mafai ona e lipotia ni aʻafiaga i le FDA i le 1-800-FDA-1088.

 

Tusitaiala

[1] Koluse DA, et al. AZD9291, o se EGFR TKI e le mafai ona suia, faʻatoʻilaloina T790M-faʻafesoʻotaʻi le teteʻe atu i EGFR taofiofia i le kanesa kanesa. Kanesa Discov. 2014 Sep; 4 (9): 1046-61.

[2] Finlay MR, et al. Faʻailoaina o se malosiʻaga ma filifilia EGFR taofiofia (AZD9291) o uma faʻamalieina ma T790M resistancemutations e faʻasao le vao ituaiga ituaiga o le receptor. J Med Chem. 2014 Oketopa 23; 57 (20): 8249-67.

[3] Hu X, Zhang ZY, et al. "O le natura anthraquinone derivative shikonin e fesoʻotaʻi ma AZD9291 faasaga i wtEGFR NSCLC sela e ala i le toe faʻaaogaina o le okesene ituaiga-faʻatulagaina endoplasmic retikulum popole." Fomaʻi. 2020; 68: 153189. PMID: 32070867

[4] Richtmann S, Wilkens D, et al. "FAM83A ma FAM83B o Prognostic Biomarkers ma gafatia New Therapeutic Target i NSCLC." Le faʻamaʻa (Basel). 2019 Me 11; 11 (5). pii: E652. PMID: 31083571

[5] Cheriyan VT, Alsaab H, et al. "O le CARP-1 aoga mimetic compound o se synergistic ma le BRAF-faʻatulagaina i le leai-laiti sela mama kanesa." Oncotarget 2018 Iulai 3; 9 (51): 29680-29697. PMID: 30038713

[6] Darren Cross1, Sue Ashton1, Caroline Nebhan2 et al. AZD9291: o le le toe suia, malosi ma filifilia le tolu augatupulaga tyrosine kinase inhibitor (TKI) faʻamoemoeina EGFR faʻagaoioia (EGFRm +) ma teteʻe (T790M) suiga i le alualu i luma māmā adenocarcinoma. Mol Cancer Ther 2013; 12 (11 Suppl): A109.

[7] Liu YN, .et al. Mauaina teteʻe atu i EGFR tyrosine kinase taofi o faʻatalanoa e ala i le toe faʻagaoioia o STC2 / JUN / AXL faailo i kanesa kanesa, Int J Kanesa, 2019, Jun 4 PMID: 31162839