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Dolastatin 10 (110417-88-4)

fua faatatau: SKU: 110417-88-4. Category:

AASraw o loʻo i ai le tuʻufaʻatasiga ma le gaosiga gafatia mai le gram i le tuʻufaʻatasiga tele o Dolastatin 10 (CAS 110417-88-4), i lalo o tulafono a le CGMP ma le faʻatonuina o le faʻaleleia lelei o le tino.

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Faamatalaga oloa

 

Dolastatin 10 video

 

 


 

I.Dolastatin 10 autu Tagata:

 

igoa: Dolastatin 10
CAS: 110417-88-4
Fua Faatatau Molecular: C42H68N6O6S
Pauna Molecular: 785.09g / mol
Melt Point: 94-95oC
Teu o le Teuina: Faleoloa i se malulu ma mago nofoaga ma i le 0 - 4 ℃ mo puʻupuʻu (aso i vaiaso) poʻo -57 ℃ mo vaitaimi uumi (masina i tausaga)
Valivali: Paʻepaʻei luga-paʻepaʻe

 


 

II. Faʻaaogaina o Dolastatin 10 (110417-88-4) i le taamilosaga antitumor

 

1. Igoa:

Suafa:
Dolastatin 10 (CAS 110417-88-4), Dolastatin-10, Neuro_000215, CCRIS 7310, CID100208, NSC376128,NSC 376128, C11280, L-Valinamide, N,N-dimethyl-L-valyl-N-(2-methoxy-4-(2-(1-methoxy-2-methyl-3-oxo-3-((2-phenyl-1-(2-thiazolyl)ethyl)amino)propyl)-1-pyrrolidinyl)-1-(1-methylpropyl)-4-oxobutyl)-N-methyl-, (2S-(1(1R*(R*),2S*),2R*(1S*,2S*,3(R*))))-

 

2.Dolastatin 10 Faʻaaogaina:

Faamoemoega: Suesueina e le saienitisi faafomai le aoga ma le matautia o le anti-microtubule agent solastatin-10 i tagata gasegase ua maua i le kanesa o susu.

Metotia: E luasefulu-tasi tagata mamaʻi na maua i le kanesa o le susu metastatic na togafitiina i le dolastatin-10 i se fualaau o le 400 mcg / m2 e le bolus intousvenous i soo se 3 vaiaso.

Iʻuga: O se tasi mai 21 maʻi (5%; 95% CI: 0-24%) na maua ai se faʻamagaloga mo se umi o 113 aso. E toʻafa tagata mamaʻi na tumau pea faʻamaʻi faʻamaʻi mo le vaeluaina o aso 87. Na maua e tagata gasegase o le lua o cycles o dolastatin-10. O le gasegase o le Hematologic e agavaʻa, faʻatasi ai ma 8 o loʻo atiaʻe le 4 neutropenia, ma le 5 faʻatasi ma le vasega 3 neutropenia; tasi le 3 febrile neutropenia sa matauina. O nei faʻavae o le vasega 3 ma le 4 neutropenia na maua i le 36% o le faasologa o togafitiga. O mea e le o se mea e le o le hematologic e le masani ai.

Faaiuga: E ui ina taliaina le tala o le tiga o le dolastatin-10, ae itiiti lava le gaioiga i lenei suesuega o le kanesa o le susu.

I Vitro: Dolastatin 10 o se pentapeptide tulaga ese e vavae ese mai le sami o Dolabella auricularia. Ua maua nei faʻamatalaga in vitro e tutusa lelei lava ma Dolastatin 10 ma le Auristatin PE, o ia mea uma ua i ai GI50 o le 10-5-10-6 μg / mL (10-2-10-3 nM) i se mea faapena minipanel o laina telefoni tagata. O le antibody-drug conjugate (ADC) e aofia ai le anti-CD30 anticorps cAC10 ua tuufaatasia i le monomethyl auristatin E (MMAE), o le analogic synthetic o le inhibitor polymerization tubulin Dolastatin 10 (110417-88-4).

 

3.Warning i Dolastatin 10

O lenei oloa e mo na o suʻesuʻega, ae le mo le faʻaaogaina o tagata poʻo vailaʻau.

Mo le mauaina o se maualuga maualuga, faamolemole faamanafana le paipa i le 37 ℃ ma lulu i le ultrasonic bath mo sina taimi. E mafai ona teuina i lalo -20 ℃ mo ni nai masina.

 

4.Further instructions:

Dolastatin 10 faʻasologa
O le tuufaatasiga o le Dolastatin 10 (110417-88-4) na maeʻa e ala i le atiaeina o se tuufaatasiga lelei o vaega autu e lua o amino, Dil (6) ma Dap (11), ma sosoo ai le sosooina o vaega lima amino acid mai le C-terminal Doe .

Faʻailoga ma Iloiloga o Dolastatin 10 Analogues o loʻo i ai Heteroatoms i luga o le Amino Acid Side Chains.
O faʻalogoga talitutusa o le natura masani o dolastatin 10 e fiafia tele i le kanesa ona oa latou gaoioiga in vitro malolosi ma o latou faʻaaogaina e avea ma totogi i antibody drug conjugates (ADCs). O le suiga o le doandatin 10 matua scaffold e tele lava ina taulai i suiga o le P1, N-terminus, ma le P5, C-terminus, ma sina gauai atu i le vaega P2.

I le telefoni feaveaʻi, Dolastatin 10 (110417-88-4) o loʻo faʻaalia ai le gaioiga e faasaga i nisi o leukemia, lymphoma ma laina tumau tumutumu (e pei o le OVCAR-3 ma le NSCLC) faʻatasi ai ma le IC50 faʻamaonia mai le 0.1nM i le 10nM. O loʻo suʻesuʻeina i le taimi nei i le falemaʻi.

 


 

III. Dolastatin 10 (110417-88-4) HCML

O matou o Aprepitant pauna supplie, Aprepitant paʻu mo le faʻatau atu, Raw Aprepitant paula (170729-80-3) hplc≥98% | AASraw R&D Faʻaaliga

 


 

IV. Faʻafefea ona faʻatau Dolastatin 10 mai AASraw?

 

1.E faʻafesoʻotaʻi mai i matou i la matou imeli faiga suʻesuʻe, poʻo luga ole laiga skypesui o le au faipisinisi (CSR).
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