Lenvatinib paula (417716-92-8) - Gaosi oloa Tuuina atu
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Lenvatinib

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Lenvatinib paula o se receptor tyrosine kinase (RTK) taofiofia e taofia le kinase gaioiga o vascular endothelial tuputupu ae vaega (VEGF) taliaina VEGFR1 (FLT1), VEGFR2 (KDR), ma VEGFR3 (FLT4).

Faamatalaga oloa

Tulaga Autu

Igoa oloa Lenvatinib paula
Numera CAS 417716-92-8
Faiga Faʻavae Molecular C21H19ClN4O4
Fua Faatatau o le Umi 426.85
Synonyms 417716-92-8;

E7080;

E7080 (Lenvatinib paula);

4-[3-Chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide;

Faʻaaliga Paʻepaʻe i paʻu paʻepaʻe paʻepaʻe
Teuina ma Taulimaina Teu ia i le vevela potu ma alu ese mai le sili atu vevela ma susu.

 

Lenvatinib Powder Faʻamatalaga

Lenvatinib pauta o se vailaʻau faʻafomaʻi o le kanesa mo le togafitia o nisi ituaiga o kanesa kanesa ma isi kanesa faʻapena foi. O gaioiga na avea ma faʻateleina kinase taofiofia faasaga i le VEGFR1, VEGFR2 ma VEGFR3 kinases.

Lenvatinib paula o se ituaiga o taulaʻi togafitiga. O lona uiga e faʻatutuina se mea faʻapitoa i sela kanesa, o lona uiga o le faʻaititia o aʻafiaga e mafua mai i le faʻaleagaina o sela maloloina. Lenvatinib paula galue i le polokaina o lua gaioiga e faʻatagaina ai kanesa sela e tupu:

▪ Faʻalavelave i se polotini e faʻatupu ai le vaevaeina o sela

▪ Le poloka o le VEGF receptor, o le mafuaʻaga lea mo le angiogenesis, poʻo le atiaʻe o se sapalai o le toto i le tumo. Lenei aveʻesea le tuma mafuaʻaga o meaʻai.

 

Lenvatinib Powder Faʻavae o Gaioiga

Lenvatinib paula o se receptor tyrosine kinase (RTK) taofiofia e taofia le kinase gaioiga o vascular endothelial tuputupu ae vaega (VEGF) taliaina VEGFR1 (FLT1), VEGFR2 (KDR), ma VEGFR3 (FLT4). Lenvatinib efuefu taofia foi isi RTKs na aafia i le pathogenic angiogenesis, tuputupu ae, ma kanesa alualu i luma i le faaopoopo atu ia latou masani feaveaʻi sela, e aofia ai fibroblast tuputupu ae vaega (FGF) mauaina FGFR1, 2, 3, ma le 4; o le platelet na tupu mai ai le tuputupu aʻe vaega taliaina alpha (PDGFRα), KIT, ma RET.

 

Lenvatinib Powder Talosaga

♦ Mo le togafitia o tagata mamaʻi ua maua i le lotoifale pe faʻasolosolo i luma, alualu i luma, radioactive iodine-refactory eseʻese kanesa o lou thyroid.

♦ I le tuʻufaʻatasia ma le vailaʻau everolimus, mo le togafitia o le alualu i luma sela sela sela pe a uma le tasi muamua anti-angiogenic togafitiga.

♦ Togafitiga o le hepatocellular (muamua ate) kanesa.

♦ Faʻatasi ma le vailaʻau oona pembrolizumab mo togafitiga o tagata mamaʻi ma le kanesa o le endometrial.

Faʻaaliga: Afai o se vailaʻau ua faʻamaonia mo le tasi faʻaaogaina, fomaʻi mafai filifili e faʻaogaina le tutusa vailaʻau mo isi faʻafitauli pe a latou talitonu e ono aoga.

 

Lenvatinib Powder Itu Aafiaga & Lapataiga

Maua se fesoasoani faafomaʻi faʻapitoa pe afai o iai lau faʻailoga o se faʻafitauli o le faʻalavelave; manava malosi; fulafula o ou foliga, laugutu, laulaufaiva, poo le faai.

Nisi tagata aveina le paʻu lenvatinib ua atiina ae se ala (se pu poʻo loimata) poʻo se fistula (o se auala masani) i totonu o le manava poʻo le manava. Valaʻau lau fomaʻi pe a fai e tiga tele lou manava, pe afai e te lagona e pei o oe o laoa ma gagging pe ae ai pe inu.

 

Valaʻau foʻi i lau fomaʻi i le taimi e tasi pe a fai oe i ai:

▪ ogaoga le manava tata;

▪ tiga le ulu, le mautonu, suia ile tulaga ole mafaufau, leiloa se vaʻai, faoa faamalosi (maʻi o le mafaufau);

▪ laititi pe leai foi se mimi;

▪ Toto e le masani ai (isu o le isu, palapala toto totoga mamafa), poʻo seisi lava palapala toto e le taofia;

▪ faʻailoga o le manava ua tafetotoi ile toto - poʻo nofo tuai, faʻasusu le toto poʻo le puaʻi e pei o kofe kofe;

▪ faʻafitauli i le fatu - tiga o le fatafata, tiga i lou auvae poʻo tauʻau, fulafula, vave oso mamafa, lagona le lava le manava;

▪ faʻailoga ole toto - faʻafuaseʻi poʻo le vaivai, faʻafitauli ile vaʻai poʻo le tautala;

▪ faʻafitauli o le ate - miaga pogisa, fata paʻu palapala, jaundice (samasama o le paʻu po o mata);

▪ maualalo le kalasiumalosi – maso maso poʻo le faʻapipiʻiina, niniva poʻo se lagona paʻu (i lou gutu, poʻo ou tamailima ma tamaivae);

▪ faʻateleina le toto - ogaoga le tiga o le ulu, faʻanenefu le vaʻai, o loulou i lou ua poʻo taliga, atuatuvale, maʻi isu.

O au togafitiga kanesa e ono faʻatuai pe le toe faʻaauauina pe a iai ni ou aʻafiaga.

 

O aʻafiaga lautele masani e aofia ai:

▪ palapala toto;

▪ tiga o le manava, niniva, puaʻi, manava tata;

▪ leai se fiaai, leai se fia taumafa;

▪ faʻataʻitaʻiga ole faʻaogaina ole thyroid;

▪ maso poʻo tiga soʻoga;

▪ fula i ou lima ma ou vae;

▪ papala gutu;

▪ mumu, mageso, poʻo paʻu le paʻu i ou lima poʻo ou vae;

▪ tiga le ulu, lelava;

▪ tale, faʻafitauli manava, leo le gaoia.

E leʻo se lisi atoa o aʻafiaga i itu ma isi e ono tupu. Valaau lau fomaʻi mo fautuaga faʻafomaʻi e uiga i aʻafiaga o le itu. E mafai ona e lipotia aʻafiaga i le FDA i 1-800-FDA-1088.

 

Tusitaiala

[1] US Taumafa ma Vailaʻau Faʻafoeina. Hematology / Oncology (Kanesa) Faʻamaonia & Faʻasilasilaga saogalemu.

[2] Haberfeld H, ed. (2015). Austria-Codex (i le Siamani). Vienna: Österreichischer Apothekerverlag.

[3] "Lenvatinib paʻu faʻatasi ma Everolimus". US Taumafa ma Vailaau Faʻafoeina. 16 Me 2016.

[4] Fomaʻi faʻataʻitaʻi numera NCT01321554 mo le "Se Faʻataʻitaʻiga o le E7080 i le 131I-Refractory Eseesega Kanesa o Lou Vaʻaia" i ClinicalTrials.gov.

[5] Lubitz CC, Kong CY, McMahon PM, et al. Tausaga faʻaletupe aʻafiaga o le eseʻeseʻese ese togafitiga o kanesa thyroid i le United States. Kanesa 2014; 120: 1345–1352.

[6] Lenvima (lenvatinib paʻu) sela [faʻatonuina faʻamatalaga]. Woodcliff Lake, NJ: Eisai Inc; Fepuari 2015

[7] Eisenhauer EA, Therasse P, Bogaerts J, et al. Fou tali iloiloga taiala i mautu tumors: toe teuteuina taiala Faʻaola (lomiga 1.1). Eur J Kanesa. 2009; 45: 228–247.

[8] Schlumberger M, Tahara M, Wirth LJ, et al. Lenvatinib paula faʻatusatusa i le placebo i le radioiodine-refactory thyroid cancer. N Engl J Med. 2015; 372: 621–630.