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Motaxantrone HCL paula

fua faatatau:
5.00 i fafo mai 5 e fua i luga 1 tagata e faaaogāina auaunaga rating
SKU: 70476-82-3. Category:

AASraw o loʻo i ai le tuʻufaʻatasiga ma le gaosiga gafatia mai le gram i le tuʻufaʻatasiga o le paʻu o le Mitoxantrone HCL (70476-82-3), i lalo o le CGMP tulafono faatonutonu ma le siakiina lelei o le faʻaleleia o le tino.

Mitoxantrone hydrochloride paʻu o se vailaʻau o le kanesa lea e faalavelaveina ai le tuputupu ae ma le salalau o vaega o le kanesa i le tino. Motaxantrone HCL paula ua faʻaaoga e togafitia ai le kanesa o le prostate ma nisi ituaiga o leukemia. O le paʻu o le Mitoxantrone HCL o loʻo faʻaaogaina foi e togafitia ai faʻaalia o le toe faʻafoʻiina o le tele o le sclerosis. O lenei vailaʻau e le faʻamaloloina ai le tele o siaki.

Faamatalaga oloa

Mitoxantrone hydrochloride paʻu video


Mitoxantrone hydrochloride paʻu Uiga masani

igoa: Mitoxantrone hydrochloride paʻu
CAS: 70476-82-3
Polokalame Molecular: C22H30Cl2N4O6
Taumaʻa Masele: 517.4
Melt Point: 160-162 ° C
Teu o le Teuina: Failautusi
Valivali: Paʻepaʻe paʻepaʻe pe paʻe paʻepaʻe


Mitoxantrone hydrochloride paʻu i le faʻaaogaina

Igoa

Igoa Suafa: Novantrone
Suafa Suafa: 1,4-dihydroxy-5,8-bis [[2- [2-hydroxyethyl] amino] ethyl] amino] 9,10-anthracenedione dihydrochloride

Motaxantrone hydrochloride paʻu Usage

Acute Myeloid Leukemia

O se vaega o ituaiga togafitiga o le chemotherapy mo le faamagaloga o le induction i le mieloid (myelogenous, nonlymphocytic) leukemia (AML, ANLL). AML e aofia ai le faʻaaliga tele, monocytic, myelomonocytic, megakaryoblastic, ma le lekomia erythroid.

Faʻaaogaina faʻatasi ma isi faʻamaʻi faʻasaina i le faʻamalosia o togafitiga e faʻaleleia pe a uma ona faʻamaonia le faʻamagaloga atoa.

Mamanu o le Setete
Faʻaaogaina o se isi tulafono mo uluai togafitiga faʻapitoa o mea ua leva, faʻamaʻi (ie, tiga) hormone-cancer-prostitution prostate (faʻatasi ma prednisone). O le muaʻi laina muamua o togafitiga mo le hormone-o le kanesa o le prostate metastatic e le faʻafefeteina o docetaxel faʻatasi ma le prednisone.

Tele sikuea (MS)
Togafitiga o le tulaga lua (faʻasolosolo) alualu i luma, alualu i luma-toe faʻalogo, poʻo le faʻateteleina o le toe faʻafoʻi-toe tuʻuina atu o MS. Faʻaaoga e faʻaititia ai le le atoatoa o le neurologic ma / poʻo le taimi ole toe foʻi.

O loʻo suʻesuʻeina i tagata gasegase i mamanu nei: Faʻateleina le faʻaletonu o le tino poʻo le leai foi o faʻataʻitaʻiga o le falemaʻi (tulaga lua alualu i luma ma le alualu i luma-subtypes) ma toe foʻi atu i le falemaʻi e mafua ai ona faʻalauteleina le le atoatoa, faatasi ai ma le tulaga masani o le neurologic i le va o toe faʻagasolo (faʻaleagaina le toe foi mai- toe tuʻuina atu faʻamaʻi).

E le fautuaina mo le faʻaaogaina o tagata gasegase i le MS progressive muamua.

E le tatau ona faʻaaogaina mo le togafitia o MS i tagata mamaʻi i le laina LVEF <50% (silasilaMotocardial Toxicity in Warned Boxed). E masani lava e le fautuaina mo le faʻaaogaina ia i latou e faʻaleagaina le tino (silasila i le Faʻasologa o le Hepatic under Cautions) poʻo i latou e iai le neutrophil count <1500 / mm3.

Lymphoma Non-Hodgkin's
Faʻaaogaina o se vaega o le faʻasologa o togafitiga o le chemotherapy mo le togafitiga o le lymphoma o le non-Hodgkin's †.

O le a le metotia o le mitoxantrone hydrochloride paʻu

Maua e pei o le Mitoxantrone hydrochloride paʻu; vailaau o loʻo faʻamatalaina i tulaga o le mitoxantrone HCL paula.

matutua
Acute Myeloid Leukemia
Faʻamālōlōina o togafitiga
IV
12 mg / m2 i aso uma i aso 1-3 faʻatasi ma le Xarau 100 mg / m2 i le aso (faʻaauau pea le IV IVusion) i aso 24-1.

Afai e le atoatoa le tali atu i le antilekekemic response i le uluai induction course, o le vasega lona lua o le induction e aofia ai 2 aso o mitoxantrone HCL paʻu (12 mg / m2 i aso taitasi) ma 5 aso o le cytarabine (100 mg / m2 i aso taitasi).

Afai e mataʻituina ogaoga ogaoga i le taimi o le uluai induction course, taofi le lua induction seʻia oʻo ina faʻamautu le afaina.

Tuufaatasiga o le Tuufaatasia
IV
12 mg / m2 i aso uma i aso 1 ma 2 faʻatasi ma le Xaraumine 100 mg / m2 i aso taʻitasi (faʻaauau pea le IV IVusion) i aso 24-1. Faʻafoeina le uluai faʻasalalauga e tusa ma le 5 vaiaso pe a uma le aʻoga faaiu mulimuli; faʻatautaia le vasega faʻamalosia lona lua masani 6 vaiaso pe a uma le amataga.

Mamanu o le Setete
IV
12-14 mg / m2 i aso uma 21 aso; ia tuʻuina atu o se mea faʻapipiʻi i togafitiga corticosteroid (faʻataʻitaʻiga, prednisone 5 mg faʻalua faalua i aso uma, hydrocortisone 40 mg faʻamalosi i aso uma). O nisi o fomaʻi e fautuaina le taofia o le mitoxantrone HCL pau (ma le faaauauina o le corticoroids) i tagata gasegase o loo tali mai pe a maeʻa le moaxantrone HCL o le pau o le 140 mg / m2 ona o le lamatia o le gasegase fatu.

Sclerosis tele
IV
12 mg / m2 i masina taʻitasi uma 3.

Faatonuina o Tapulaa
matutua
Sclerosis tele
IV
Laʻasaga maualuga o le olaga atoa: 140 mg / m2.

Tulaga Faapitoa
Faʻasalaga Lelei
Faʻaitiitia le faʻamaonia; E mafai ona manaʻomia fetuʻutuʻunaiga o fuainumera, ae ui i lea, leai ni faʻataʻotoga o fetuutuunaiga. (Vaʻaia le Faʻasalaga o le Hepatic under Cautions.)

Renal Impairment
E le manaʻomia le faʻaitiitia o le faʻaaoga.

lapataʻiga

Aafiaga o le Supervising Clinician

Faʻafoe naʻo lalo o le vaavaaiga a fomaʻi agavaa i le faʻaaogaina o le togafitiga cytotoxic.

Lapataiga o le Pulega
Faʻafoe lemu i se vaifofo e fafaga fua IV. Aua le faʻatinoina e le IM, sub-Q, faʻaaogaina, poʻo le iniseti.

Lagona malosi o le tino pe a fai e toe faʻalavelave. (Vaʻaia Aafiaga Faʻalotoifale i lalo o Faʻamatalaga.)

Tigā ma o nisi taimi e le mafai ona faʻamalosia e mafua mai i le taʻavale o loʻo lipotia pe a maeʻa le pulega faʻapitoa. (Tagai i le Neurotoxicity i lalo o Faʻatonu.)

Myelosuppression
E mafai ona tutupu le mielosuppression matuia. E masani ona aloese mai le faʻaaogaina o tagata mamaʻi i le neutrophil count <1500 / mm3, sei vagana ai togafitiga o le myeloid (myelogenous, nonlymphocytic). Mataʻituina ma le faʻaeteete le tulaga o le hematologic. (Tagai i le Hematologic Effects under Cautions.)

Matuʻaiga o le myocardial
Malosiaga o le cardiotoxicity ma le CHF e ono lamatia i le taimi poo masina i tausaga mulimuli ane i togafitiga; lamatiaga faateleina i le faateleina o le fua faatupulaia.

Faʻamatalaga o aʻafiaga (faʻasolopito o poʻo le maʻi o le cardiovascular o loʻo i ai nei, faʻamuamua poʻo le faʻasalaga i le vaega o le mediastinal / pericardial, togafitiga faʻamuamua ma isi anthracycline poʻo togafiti, poʻo le faʻaaogaina o isi vailaʻau cardiotoxic) e mafai ona faʻaititia ai le lamatiaga o le cardiotoxicity. Ae ui i lea, e ono tulaʻi mai le tulaga e tusa lava pe o iai ni aʻafiaga lamatia o le loto. (Vaai Cardiotoxicity i lalo o Faʻasalaga.)

O le aʻafiaga o le CHF o loʻo atiaʻe i tagata mamai o le a avea ma 2.6% i le fua faʻateleina o le 140 mg / m2.

Aʻo lei amataina le togafitiga, iloilo uma tagata gasegase mo faailoilo fatu / faailoga e ala i le talafaasolopito ma suʻesuʻega faaletino ma fuafua ai le vaevaega ole vaega faʻasolosolo o le tuuga ole ventricular (LVEF) i le echocardiogram poo le faʻateleina o radionuclide angiography (MUGA).

Aua e te amataina le togafitiga i tagata mamaʻi ma le tele o sclerosis pe afai o le LVEF autu o le <50%.

I tagata gasegase e tele le sclerosis, iloilo le LVEF e le echocardiogram poʻo le MUGA ao leʻi oʻo i fualaau taʻitasi; 'aua le faʻatulagaina ni vailaʻau faʻaopopo pe afai e faʻaitiitia le LVEF i le <50% poʻo pe afai e tupu se faʻafitauli taua i le LVEF.

E le tatau ona maua e le tagata maʻi e tele le sclerosis le fua faʻateleina> 140 mg / m2.

Maualuga Leukemia Miselogenous Leukemia (AML)
Maualuga AML lipotia i tagata gasegase e togafitia i le mitoxantrone HCL paula; lamatiaga o le lekomisi lona lua maualalo pe a tuufaatasia le anthracycline ma isi antineoplastics DNA-faaleagaina, pe a uma ona faalauiloaina tele fualaau oona, pe pe a faateteleina foi le gasegase o le anthracycline (Tagai Carcinogenicity under Cautions.)

Mitoxantrone hydrochloride Maea Maea

Min poloaiga 10grams.
O le suʻesuʻega i le aofaʻi masani (I totonu ole 1kg) e mafai ona lafo i 12 itula pe a uma ona totogi.
Mo se faasologa sili atu e mafai ona tuʻuina atu ile 3 aso faigaluega pe a uma le totogiina.

Mitoxantrone hydrochloride paʻu Mataʻitusi

Ia saunia i le lumanai.

Le Paʻu o le Mitoxantrone HCL o Soʻo se Itū Faʻafeagai

E mafua mai le afaina o le tino o le mitoxantrone e aofia ai: faʻamaʻi pipisi, faʻamaʻi pipisi o le tino, siama pipisi, afaina o le paʻu, lepsis, alopecia, amenorrhea, gasegase cardiac, faamaʻi, manava, gasegase o le gasegase, gase-glutamyl transferase, leukopenia, malestrual disease, nausea, stomatitis, mea e le masani ai le urine, tiga o le manava, maʻi stomatitis, asthenia, lagona mumū o le gastrointestinal tract, tale, faaitiitia hemoglobin, faaitiitia le toto toto toto, dyspnea, edema, tiga tiga, vaivai, fiva, hematuria, hyperglycemia, hypocalcemia, hypokalemia, tele glucose serum, lymphocytopenia, mucositis, pharyngitis, rhinitis, tiga o le manava, thrombocytopenia, vomiting, gaioiga mamafa, le masani ai neutrophil numera, anorexia, malaise, ma nailbedchanges. O isi aafiaga faʻaleagaga e aofia ai le: pneumonia, faʻalavelave faʻaleagaina, faʻamaʻiina, paʻulocytopenia, maʻi tigaina, sinusitis, popole, arthralgia, conjunctivitis, faanoanoaga, dyspepsia, gasegase mamafa o le toto, totoga, toto maualuga, hyponatremia, maʻi vaivai, faʻateleina le ogaoga alanine aminotransferase, faʻateleina o le serum aspartate aminotransferase, faʻamaʻi o le fatu o le ischemic, myalgia, tiga, petechia, proteinuria, vaʻaia, tuʻimomomo, vavao, diaphoresis, ma ecchymoses. Vaʻai i lalo mo se lisi tele o aʻafiaga leaga.


E faʻapefea ona faʻatau le Mitoxantrone hydrochloride paʻu mai AASraw

1.E faʻafesoʻotaʻi mai i matou i la matou imeliAvanoa suʻesuʻega, poʻo le skypeAvanoasui o le au faipisinisi (CSR).
2.E tuʻu mai ia i matou le tele o au fesili ma lau tuatusi.
3.Our CSR o le a tuʻuina atu ia te oe le upusii, taimi o totogi, numera o le suʻega, auala e tuʻuina atu ai ma le aso atofaina e taunuu ai (ETA).
4.Payment na faia ma o oloa o le a auina atu i itula 12 (Mo le faʻasalalauga i totonu ole 10kg).
5.Goods na maua ma tuuina mai ni faʻamatalaga.

FAUFUAGA MA TALANOA:

O lenei Mea ua Faʻaaoga Mo Suesuega Faʻaaoga Naʻo. Faʻamaumauga o le Faʻatauga. E le mo le Faʻatauga a le Tagata, poʻo le Fomaʻi, Vailaʻau Vaʻaia, poʻo le Aiga.


COA

COA 70476-82-3Mitoxantrone HCL pauu AASRAW

HNMR

O matou o le Mitoxantrone hydrochloride faʻamalosia o le eletise, Motaxantrone HCL paʻu o le faʻatau, faʻatau oloa mai le eletise Raw Mitoxantrone HCL (70476-82-3) hplc≥98% | AASraw

Recipes

Mitoxantrone hydrochloride Faʻasologa Malamalama Maea

Faʻatalanoaina o matou Tagata Faʻatau (CSR) mo auiliiliga, mo lau faʻamatalaga.

Faʻamatalaga & faʻamaumauga o oloa