MMAD (Demethyldolastatin 10)

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AASraw o loʻo i ai le faʻasologa ma le gaosiga gafatia mai le gram i le tuʻufaʻatasiga o MMAD (Demethyldolastatin 10) (CAS 203849-91-6), i lalo o le CGMP tulafono faatonutonu ma le siakiina lelei o le faiga o le puleaina lelei.

gata i lea, MMAD ua lipotia mai o le a faʻaaogaina i le gaosiga o vailaau faʻasao e faʻasao ai le faʻamaʻi (NDCs). I le NDCs, ua tuufaatasia MMAD ma le anti-5T4 antibody poo anti-Her2 antibody. Ua faaalia ai o le NDC e sili atu le aoga ma le pharmacokinetics.

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MMAD (Demethyldolastatin 10) vitio


MMAD (Demethyldolastatin 10) uiga autu

igoa: MMAD (Demethyldolastatin 10)
CAS: 203849-91-6
Polokalame Molecular: C41H66N6O6S
Taumaʻa Masele: 771.06
Melt Point: N / A
Teu o le Teuina: Powder -20 ° C 3 tausaga
4 ° C 2 tausaga
I masina faʻaalu -80 ° C 6
-20 ° C 1 masina
Valivali: Paʻepaʻe i luga-papaʻe (malosi)


MMAD (Demethyldolastatin 10) (203849-91-6) faʻaaogaina i le uila

Igoa

Synonyms: Demethyldolastatin 10 (203849-91-6); Monomethylauristatin D; Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

Lapataiga i MMAD (Demethyldolastatin 10)

E leʻo faʻamaonia atoatoa le oloa mo togafitiga faafomaʻi. Mo naʻo suʻesuʻega e faʻaaoga

Mo le mauaina o se maualuga maualuga, faamolemole faamanafana le paipa i le 37 ℃ ma lulu i le ultrasonic bath mo sina taimi. E mafai ona teuina i lalo -20 ℃ mo ni nai masina.

Isi faatonuga

I Vitro: MMAD (Demethyldolastatin 10) (203849-91-6) ua faʻapipiʻiina e ala i se faiga o le oxime-ligation faʻamalosi e maua mai ai le faʻamaʻi faʻamaʻi-anti-drug-conjugates (ADCs) faʻatasi ma le fualaau o fualaau-to-antibody o le ~ 2.0. O le mea na maua ai e le au faʻataʻitaʻiga o loʻo faʻaalia ai le lelei o le falemaʻi, o le gasegase o le cytotoxic activity faasaga i le HER2. Pe a faʻatusatusa atu i ADCs ua saunia e le cysteine ​​alkylation pe a maeʻa le faʻaleagaina o le vaeluaga o le vaeluaga o le vaeluaga, faʻaalia i le site-faapitoa-ADCs-faʻa-amino-based-ADCs ua faʻaalia le faateleina o le cytotoxicity in vitro

I Vivi: O le mea e tupu mai i le antibody-drug conjugates (ADCs) e faʻaalia ai le taofiofia atoatoa o le tumo i le oona. Latou te iai foʻi se faʻalauiloaina o le toxicology i kusi.


Faʻafefea ona faʻatau MMAD; faʻatau Demethyldolastatin 10 mai AASraw

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