Raw MMAF (hydrochloride) (1415246-68-2) HPLC≥98% | AASraw
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MMAF (Hydrochloride) (1415246-68-2)

fua faatatau: SKU: 1415246-68-2. Category:

AASraw o loʻo i ai le tuʻufaʻatasiga ma le gaosiga gafatia mai le gram i le tuʻufaʻatasiga o le MMAF (hydrochloride) (CAS 1415246-68-2), i lalo o tulafono a le CGMP ma le faʻatonuina o le 'auʻaunaga lelei o le faʻatonutonuga.

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Faamatalaga oloa

 

MMAF (Hydrochloride) vitio

 

 


 

MMAF (Hydrochloride) uiga masani

 

igoa: MMAF (hydrochloride)
CAS: 1415246-68-2
Fua Faatatau Molecular: C39H66ClN5O8
Pauna Molecular: 768.42
Melt Point: 314.3 ° C i le 760 mmHg (Manatu)
Teu o le Teuina: Powder -20 ° C 3 tausaga
4 ° C 2 tausaga
I masina faʻaalu -80 ° C 6
-20 ° C 1 masina
Valivali: Paʻu paʻu paepae paʻepaʻe

 


 

MMAF (Hydrochloride) faʻaaogaina i le taamilosaga fomaʻi

 

Igoa

MMAF (Hydrochloride) (1415246-68-2) o loʻo taʻua foi le Monomethylauristatin F Hydrochloride, MMAF HCL

 

MMAF (Hydrochloride) Faʻaaogaina

O le saienitisi faafomaʻi e tele naʻo le MMAF, o loʻo i lalo ifo nisi o faʻamatalaga mo le faʻamatalaga:
I Vitro: MMAF faʻaalia le cytotoxicity in vitro faasaga i se laulau o laina laina. O faʻamoemoega IC50 mo Karpas 299, H3396, 786-O ma Caki-1 o 119, 105, 257, ma 200 nM, i le faasologa. O le MMAF faʻatonuina e sili atu ona malosi nai lo le fualaau faasaina, ma o faʻasalaga CAC10 o le MMAF faʻaaliga o faʻataʻitaʻiga. I luga o se faʻamatalaga, o le CAC10-L1-MMAF4 o se averesi o le 2200-sili atu le malosi nai lo le free MMAF ma o loʻo galue i luga ole CD30-positive cell line tested

I Vivo: O le maualuga faʻatapulaʻa fualaʻau i isumu o MMAF (1415246-68-2) (> 16 mg / kg) e sili atu maualuga nai lo MMAE (1 mg / kg). cAC10-L1-MMAF4 ei ai le MTD o le 50 mg / kg i isumu ma le 15 mg / kg i isumu. O le tutusa cAC10-L4-MMAF4 ADC sa sili atu ona laʻitiiti, maua MTDs i isumu ma isumu o> 150 mg / kg ma 90 mg / kg i isumu, faʻatulagaina

 

Lapataiga ile MMAF (hydrochloride)

Mo suʻesuʻega e faʻaaogaina

 

Isi faatonuga

Ua faʻamaumauina o Monomethylauristatin F Hcl (MMAF Hcl) o se antitubulin e faʻasaʻo le vavaega o le cell e ala i le taofia o le polymerization o le tubulin; ma o le gaiototoxicity o le gaiototoxicity e maualalo ifo i le MMAE; ma o se antibody le cytotoxin.

Sosa Cell
O sela e togafitia i le faʻatupuina o vailaʻau o suʻesuʻega mole mūmū ma faʻapipiʻiina le 4-6 aso faʻamoemoeina i laina laina. Suʻesuʻega o le faʻaolaolaina o sela ma faʻaititia le faʻaititia e maua ai le taua o le IC50 o loʻo faia e ala i le faʻaaluina o le suauʻu o le Alamar Blue
MCE e leʻi faʻamaoniaina tutoatasi le moni o nei metotia. E na o le faʻamatalaga.

Pulega o Manu
Isumu: suʻesuʻe faʻaalia ai pe a oʻo i le subcutaneus Karpas 299 paʻu lapoʻa e oʻo atu i le 300 mm3, e tolu manu i le kulupu e maua le tui e 10 mg vaega o le tino / kg mamafa o le tino o le cAC10-L1-MMAF4 poʻo le cBR96-L1-MMAF (1415246-68-2 ) 4 faʻaaoga. O tumors e aveʻese ma tuʻu i totonu o le sili ona lelei o le vevela o le vevela, ma le 5 μm-manifinifi vaega o le aisa o loʻo pisia e faʻaaogaina ai le puipuiga o le puipuia o le tino.
MCE e leʻi faʻamaoniaina tutoatasi le moni o nei metotia. E na o le faʻamatalaga.

 


 

Faʻafefea ona faʻatau MMAF; faʻatau le hydrochloride mai AASraw

 

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