Regorafenib paula (755037-03-7) - Gaosi oloa Tuuina atu
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Regorafenib

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Regorafenib paula o se tautala tautala tele-kinase taofi e faʻatatauina angiogenic, stromal ma oncogen receptor tyrosine kinase (RTK). Regorafenib paula faʻaalia anti-angiogenic gaioiga ona o lona lua fuafuaina VEGFR2-TIE2 tyrosine kinase taofi.

Faamatalaga oloa

Tulaga Autu

Igoa oloa Regorafenib paula
Numera CAS 755037-03-7
Faiga Faʻavae Molecular C21H15ClF4N4O3
Fua Faatatau o le Umi 482.8
Synonyms Regorafenib paula;

755037-03-7;

Faga 73-4506;

Stivarga;

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide.

Faʻaaliga Paʻepaʻe i le paʻepaʻe papaʻe
Teuina ma Taulimaina Faleoloa i le vevela vevela, teu i se malulu, mago nofoaga, mamao ese mai le susulu o le la.

 

Regorafenib Powder Faʻamatalaga

Regorafenib paula o se tautala tautala tele-kinase taofi e faʻatatauina angiogenic, stromal ma oncogen receptor tyrosine kinase (RTK). Regorafenib paula faʻaalia anti-angiogenic gaioiga ona o lona lua fuafuaina VEGFR2-TIE2 tyrosine kinase taofi. Talu mai le 2009 na suʻesuʻeina o se ono mafai togafitiga i le tele o ituaiga tumo. I le 2015 e lua US faʻamaonia mo sili atu kanesa.

O le Regorafenib powder o se togafitiga faʻapitoa e faʻatatau ma fusifusia i tyrosine kinase taliaina ma taofia ai le faʻatupuina o le tuputupu ae o le epidermal factor (EGFR) ma le vascular endothelial tuputupu aʻe vaega (VEGF), mauaina i luga o le sela. I le fusifusia i nei talipupuni regorafenib paula poloka poloka se taua auala e faʻalauteleina ai sela vaevaega.

 

Regorafenib Powder Faiga o Gaioiga

Regorafenib paula o se laʻititi laʻititi poloka poloka o tele membrane-fusifusia ma intracellular kinases aafia i masani sela sela gaioiga ma i pathologic gaioiga pei o oncogenesis, tuma angiogenesis, ma le tausiga o le tuma microen environment. I in vitro biochemical poʻo cellular suʻega, regorafenib paʻu poʻo lona sili malosi tagata faʻaaoga metabolites M-2 ma M-5 taofia le gaioiga o RET, VEGFR1, VEGFR2, VEGFR3, KIT, PDGFR-alpha, PDGFR-beta, FGFR1, FGFR2, TIE2 , DDR2, TrkA, Ef2A, RAF-1, BRAF, BRAFV600E, SAPK2, PTK5, ma Abl i faʻasologa o le regorafenib paʻu ua ausia falemaʻi. I totonu vivo faʻataʻitaʻiga, regorafenib paula faʻaalia anti-angiogenic gaioiga i le isumu tumo faʻataʻitaʻiga, ma le taofiofia o le tuputupu aʻe faʻapea foi ma le anti-metastatic gaioiga i le tele o isumu xenograft faʻataʻitaʻiga e aofia ai ma nisi mo tagata colorectal carcinoma.

 

Regorafenib Powder Talosaga

Regorafenib paula o le faʻatatauina kanesa fualaʻau. Atonu e te ono avea o se togafitiga mo:

▪ Gastro kanesa stromal kanesa (GIST) - o se ituaiga seasea o malulu palapala sela o le manava poʻo le manava;

▪ Maualuga kanesa na amata i le ate (muamua kanesa kanesa).

 

Regorafenib Powder Itu Itu & Lapataiga

Matou te leʻi lisiina uma aʻafiaga. E foliga mai e te le o maua uma nei aʻafiaga, ae ono i ai nisi o ia taimi i le taimi e tasi.

Faʻafia ma pe o le a le ogaoga o aʻafiaga e mafai ona fesuiaʻi mai lea tagata i lea tagata. Latou te faʻamoemoe foʻi i isi togafitiga o loʻo e faia. Mo se faʻataʻitaʻiga, o au aʻafiaga itu e mafai ona sili atu le leaga pe afai o loʻo e i ai isi vailaʻau poʻo radiotherapy.

 

Aafiaga masani masani

▪ Faateleina le ono maua ile siama

▪ Manava ma foliga sesega

▪ Ogaoga, pulu nifo poʻo nifo isu

▪ Lava ma vaivaiga (lelava)

▪ Paʻu, mumu ma paʻu luga o alofilima ma alofivae

▪ Leai o le fiaai ma le paʻu o le pauna

▪ Manava

▪ Suiga leo

▪ Suiga leo

▪ O papala ma papala

▪ E suia le paʻu

▪ Lagona pe ua maʻi

▪ Maualuga maualuga ole bilirubin

▪ Maualuga le vevela (fiva)

 

Tusitaiala

[1] "Bayer Faʻalauiloa Fou Faʻamatalaga e uiga i le Oncology Portfolio Ia Faʻaalia i le ECCO-ESMO Congress 2009". Toe aumai 2009-09-19.

[2] "Faʻaputuga tupe o le Kanesa mo naʻo le tasi fualaʻau, Regorafenib paula". BBC. 22 Me 2015. Toe aumai 7 Iuni 2015.

[3] Faʻamaonia e le FDA Oloa O vailaʻau: STIVARGA (regorafenib paʻu) fofoga tautala

[4] Kim J, Ulu A, Wan D, Yang J, Hammock BD, Weiss RH (Me 2016). "Faʻaopopoina o le DHA Synergistically Faʻamalosia le aoga o Regorafenib paʻu mo Fatugaʻo Kanesa Togafitiga". Vailaau Molecular Kanesa. 15 (5): 890–8.

[5] Hotta K, Ueyama J, Tatsumi Y, Tsukiyama I, Sugiura Y, Saito H, Matsuura K, Hasegawa T: Le lava o Saofaga o Multidrug Resistance-fesoʻotaʻi Protein ma Organic Anion-felauaʻi Polypeptide i Pharmacokinetics o Regorafenib paʻu, a Novel Tele-Kinase Inhibitor, i Isumu. Anticancer Res. 2015 Sep; 35 (9): 4681-9.