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FA'-438

fua faatatau: Category:

TAK438, e faʻaigoa foʻi ia Vonoprazan Fumarate, o se vailaʻau fou mo le togafitia o faʻamaʻi e fesoʻotaʻi ma le acid ma se faiga fou o gaioiga e taʻua o le potassium-faatauva poloka poloka (P-CABs) e faʻatauvaʻa taofiofia le fusifusia o potasioni iona i H +, K + -ATPase ( lauiloa foi o le proton pump) i le laʻasaga mulimuli o le gastric acid faʻalilolilo i gastric sela sela, pulea gastric acid faʻalilolilo. E maua ai le malosi ma tumau lagolagoina vaivaiga taofiofia aafiaga.

Faamatalaga oloa

Tulaga Autu

Igoa oloa FA'-438
Numera CAS 1260141-27-2
Faiga Faʻavae Molecular C21H20FN3O6S
Fua Faatatau o le Umi 461.46
Synonyms Vonoprazan Fumarate;
TAK-438;
1260141-27-2;
Vonoprazan fumurate;
TAK438.
Faʻaaliga Paʻepaʻe i paʻu paʻepaʻe paʻepaʻe
Teuina ma Taulimaina Faʻamago, pogisa ma i le 0 - 4 C mo se taimi puʻupuʻu (aso i vaiaso) poʻo le -20 C mo se taimi umi (masina i tausaga).

 

TAK-438 Faʻamatalaga

TAK438, e faʻaigoa foʻi ia Vonoprazan Fumarate, o se vailaʻau fou mo le togafitia o faʻamaʻi e fesoʻotaʻi ma le acid ma se faiga fou o gaioiga e taʻua o le potassium-faatauva poloka poloka (P-CABs) e faʻatauvaʻa taofiofia le fusifusia o potasioni iona i H +, K + -ATPase ( lauiloa foi o le proton pump) i le laʻasaga mulimuli o le gastric acid faʻalilolilo i gastric sela sela, pulea gastric acid faʻalilolilo. E maua ai le malosi ma tumau lagolagoina vaivaiga taofiofia aafiaga.

I le gaosia o manava o le manava, o le TAK-438 togafitiga na mafua ai le umi ma le malosi o le faʻavaeina o le acid. O le taofiofi aafiaga o le TAK-438 i le faʻamauina o le acid foliga mai e fesoʻotaʻi ma gastric parietal sela physiology.

 

FA'-438 Mechanism of Action

TAK-438 (Vonoprazan fumarate) o se pyrole derivative ma potassium-faatauva poloka poloka (P-CAB) e faatauva poloka le potassium-fusifusia nofoaga o gastric H (+), K (+) - ATPase, o se ki autu i le gaioiga. o faʻalilolilo acid gastric. E mafai e le lotoa ona faaputuputu i siosiomaga siosiomaga ma e tatau ona maua ai se umi atu o le taofiofia ona o le alkaline pKa o le 9.06.

I le gaosia o manava o le manava, o le TAK-438 togafitiga na mafua ai le umi ma le malosi o le faʻavaeina o le acid. O le taofiofi aafiaga o le TAK-438 i le faʻamauina o le acid foliga mai e fesoʻotaʻi ma gastric parietal sela physiology.

 

TAK-438 Talosaga

TAK-438 (Vonoprazan fumarate poʻo Vonoprazan) o se vailaʻau fou mo le togafitia o faʻamaʻi e faʻatatau i le acid ma se faiga fou o gaioiga e taʻua o le potassium-faatauva poloka poloka (P-CABs) e faʻatauvaʻa taofiofia le fusifusia o potasi ioni i H +, K + -ATPase (e faʻaigoa foʻi ole proton pump) ile laʻasaga mulimuli ole faʻamalama ole gastric acid ile gastric parietal cells. Ua faʻamaonia le vailaʻau i Iapani mo le togafitia o faʻamaʻi e fesoʻotaʻi ma le acid, e aofia ai le papala tau kesi, papala duodenal, reflux esophagitis ma Adjunct i le Helicobacter pylori faʻamamaina i le tulaga o Helicobacter pylori gastritis.

 

TAK-438 Itu Aʻafiaga & Lapataʻiga

O aʻafiaga masani masani aofia ai:

▪ manava tatā,

▪ niniva ma puaʻi,

▪ papala,

▪ tiga o le manava,

▪ paʻu o le paʻu,

▪ susunu o le fatu.

 

E leʻo uma ia ono afaina o le TAK438. Mo nisi faʻamatalaga, fesili i lau fomaʻi poʻo le faletalavai. Valaʻau lau fomaʻi mo fautuaga faʻafomaʻi e uiga i aʻafiaga. E mafai ona e lipotia ni aʻafiaga i le FDA i le 1-800-FDA-1088.

 

Tusitaiala

[1] Arikawa Y, Nishida H, Kurasawa O, Hasuoka A, Hirase K, Inatomi N, Hori Y, Matsukawa J, Imanishi A, Kondo M, Tarui N, Hamada T, Takagi T, Takeuchi T, Kajino M. Discovery of a novel pyrrole derivative 1- [5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e fumarate (TAK-438) o se potassium-faatauva acid poloka (P-CAB) J Med Chem. 2012 Me 10; 55 (9): 4446-56. faia: 10.1021 / jm300318t. Epub 2012 Ape 30. Faʻasalalau PMID: 22512618.

[2] Kondo M, Kawamoto M, Hasuoka A, Kajino M, Inatomi N, Tarui N. Maualuga siakiina siaki o potassium-faatauva poloka poloka. J Biomol Lau. 2012 Fep; 17 (2): 177-82. faia: 10.1177 / 1087057111421004. Epub 2011 Sep 22. PubMed PMID: 21940711.

[3] Shin JM, Inatomi N, Munson K, Strugatsky D, Tokhtaeva E, Vagin O, Sachs G. Faʻailogaina o se tala fou potassium-faatauva poloka poloka o gastric H, K-ATPase, 1- [5- (2- fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438). J Pharmacol Exp Ther. 2011 Nov; 339 (2): 412-20. faia: 10.1124 / jpet.111.185314. Epub 2011 Aug 9. PubMed PMID: 21828261; PubMed Central PMCID: PMC3199995.

[4] Hori Y, Matsukawa J, Takeuchi T, Nishida H, Kajino M, Inatomi N. O se suʻesuʻega faʻatusatusaina o le antisecretory aafiaga o TAK-438, o se tala fou potassium-faatauva acid poloka, ma lansoprazole i manu. J Pharmacol Exp Ther. 2011 Iuni; 337 (3): 797-804. faia: 10.1124 / jpet.111.179556. Epub 2011 Mati 16. PubMed PMID: 21411494.

[5] Matsukawa J, Hori Y, Nishida H, Kajino M, Inatomi N. O se faʻatusatusaga suʻesuʻega i auala o gaioiga a TAK-438, o se tala fou potassium-faatauva acid poloka, ma lansoprazole i muamua galueaina lapisi lapisi lapisi. Biochem Pharmacol. 2011 Me 1; 81 (9): 1145-51. faia: 10.1016 / j.bcp.2011.02.009. Epub 2011 Mati 1. PubMed PMID: 21371447.

[6] Hori Y, Imanishi A, Matsukawa J, Tsukimi Y, Nishida H, Arikawa Y, Hirase K, Kajino M, Inatomi N. 1- [5- (2-Fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438), o se tala fou ma malosi potassium-faatauva poloka poloka mo le togafitia o acid-faʻamaʻi faʻamaʻi. J Pharmacol Exp Ther. 2010 Oketopa; 335 (1): 231-8. faia: 10.1124 / jpet.110.170274. Epub 2010 Iulai 12. PubMed PMID: 20624992.