Faamatalaga oloa
Tulaga Autu
Igoa oloa | FA'-438 |
Numera CAS | 1260141-27-2 |
Faiga Faʻavae Molecular | C21H20FN3O6S |
Fua Faatatau o le Umi | 461.46 |
Synonyms | Vonoprazan Fumarate; TAK-438; 1260141-27-2; Vonoprazan fumurate; TAK438. |
Faʻaaliga | Paʻepaʻe i paʻu paʻepaʻe paʻepaʻe |
Teuina ma Taulimaina | Faʻamago, pogisa ma i le 0 - 4 C mo se taimi puʻupuʻu (aso i vaiaso) poʻo le -20 C mo se taimi umi (masina i tausaga). |
TAK-438 Faʻamatalaga
TAK438, e faʻaigoa foʻi ia Vonoprazan Fumarate, o se vailaʻau fou mo le togafitia o faʻamaʻi e fesoʻotaʻi ma le acid ma se faiga fou o gaioiga e taʻua o le potassium-faatauva poloka poloka (P-CABs) e faʻatauvaʻa taofiofia le fusifusia o potasioni iona i H +, K + -ATPase ( lauiloa foi o le proton pump) i le laʻasaga mulimuli o le gastric acid faʻalilolilo i gastric sela sela, pulea gastric acid faʻalilolilo. E maua ai le malosi ma tumau lagolagoina vaivaiga taofiofia aafiaga.
I le gaosia o manava o le manava, o le TAK-438 togafitiga na mafua ai le umi ma le malosi o le faʻavaeina o le acid. O le taofiofi aafiaga o le TAK-438 i le faʻamauina o le acid foliga mai e fesoʻotaʻi ma gastric parietal sela physiology.
FA'-438 Mechanism of Action
TAK-438 (Vonoprazan fumarate) o se pyrole derivative ma potassium-faatauva poloka poloka (P-CAB) e faatauva poloka le potassium-fusifusia nofoaga o gastric H (+), K (+) - ATPase, o se ki autu i le gaioiga. o faʻalilolilo acid gastric. E mafai e le lotoa ona faaputuputu i siosiomaga siosiomaga ma e tatau ona maua ai se umi atu o le taofiofia ona o le alkaline pKa o le 9.06.
I le gaosia o manava o le manava, o le TAK-438 togafitiga na mafua ai le umi ma le malosi o le faʻavaeina o le acid. O le taofiofi aafiaga o le TAK-438 i le faʻamauina o le acid foliga mai e fesoʻotaʻi ma gastric parietal sela physiology.
TAK-438 Talosaga
TAK-438 (Vonoprazan fumarate poʻo Vonoprazan) o se vailaʻau fou mo le togafitia o faʻamaʻi e faʻatatau i le acid ma se faiga fou o gaioiga e taʻua o le potassium-faatauva poloka poloka (P-CABs) e faʻatauvaʻa taofiofia le fusifusia o potasi ioni i H +, K + -ATPase (e faʻaigoa foʻi ole proton pump) ile laʻasaga mulimuli ole faʻamalama ole gastric acid ile gastric parietal cells. Ua faʻamaonia le vailaʻau i Iapani mo le togafitia o faʻamaʻi e fesoʻotaʻi ma le acid, e aofia ai le papala tau kesi, papala duodenal, reflux esophagitis ma Adjunct i le Helicobacter pylori faʻamamaina i le tulaga o Helicobacter pylori gastritis.
TAK-438 Itu Aʻafiaga & Lapataʻiga
O aʻafiaga masani masani aofia ai:
▪ manava tatā,
▪ niniva ma puaʻi,
▪ papala,
▪ tiga o le manava,
▪ paʻu o le paʻu,
▪ susunu o le fatu.
E leʻo uma ia ono afaina o le TAK438. Mo nisi faʻamatalaga, fesili i lau fomaʻi poʻo le faletalavai. Valaʻau lau fomaʻi mo fautuaga faʻafomaʻi e uiga i aʻafiaga. E mafai ona e lipotia ni aʻafiaga i le FDA i le 1-800-FDA-1088.