Fesili e masani ona fesiligia e uiga i le Sunitinib Malate 丨 AASraw
AASraw gaosia Cannabidiol (CBD) paʻu ma Hemp Taua Suauʻu tele!

Sunitinib Malate

 

  1. Sunitinib Malate Aotelega
  2. O le a se mea e mafai ona matou faʻaaogaina Sunitinib Malate?
  3. Faʻafefea Sunitinib Malate Galue?
  4. Faʻafefea Ona Aveina Sunitinib Malate?
  5. Faʻafefea Ona Teuina Sunitinib Malate?
  6. O le a le tele o lo tatou iloa o le itu aʻafiaga o Sunitinib Malate?
  7. O a isi fualaʻau o le a aʻafia ai le Sunitinib Malate?
  8. Faʻamaonia e le FDA le Sunitinib Malate As Adjuvant Togafitiga O le sela o le sela sela
  9. O fea e mafai ona ou faʻatau ai Sunitinib Malate i luga ole laiga?

 

Sunitinib Malate (CAS:341031-54-7) na maua i le SUGEN, o le biotechnology kamupani lea na faʻataunuʻuina porotini kinase taofi. O le lona tolu i le faʻasologa o tuʻufaʻatasiga e aofia ai le SU5416 ma le SU6668. O le mafuaʻaga o se ATP mimic o le a tauva ma ATP mo le fusifusia i le catalytic nofoaga o receptor tyrosine kinases. O lenei manatu na mafua ai le fatufatuina o le tele-mole mole tyrosine kinase taofiofia, aofia ai Gleevec, Sutent, Tarceva ma le tele o isi.

 

Sunitinib Malate Aotelega

Sunitinib Malate o se samasama i le pauta pauta. Sunitinib Malate o se tamai-mole mole tele faʻatulagaina receptor tyrosine kinase (RTK) taofi O Ianuari 26, 2006, na faʻamaonia aloaʻia le sooupu e le US FDA mo faʻailoga o le togafitia o le sela o le sela o le fatu (RCC) ma le imatinib-resist gastrointestinal stromal tum (GIST). Mo nei mafuaʻaga, Sunitinib Malate e masani ona avanoa o se tuʻufaʻatasia e faia faʻamatalaga. Ua taofia e le Sunitinib Malate le saini o sela e ala i le tulimataʻi o le tele o RTK. E aofia ai ma vaega uma o le tupuʻaga o le tupuola o mea tutupu (PDGF-R) ma le faʻatupuina o le tuputupu aʻe o le endothelial (VEGF-R). O le Sunitinib Malate e taofia ai foi le KIT (CD117), o le RTK o loʻo unaʻia le tele o GIST. I se faʻaopopoga, Sunitinib Malate taofia isi RTKs aofia ai RET, CSF-1R, ma flt3.

 

O le a se mea e mafai ona matou faʻaaogaina Sunitinib Malate? 

Sunitinib Malate o loʻo faʻaaogaina e togafitia ai tagata matutua ma le kanesa o le fatugaʻo e leʻo sosolo (localized) ma i latou o loʻo i ai le ono ono maua o le RCC toe foʻi mai pe a maeʻa ona taotoga fatugaʻo.

Sunitinib Malate o loʻo faʻaaogaina e togafitia ai le kanesa o le fatugao alualu i luma (advanced renal cell carcinoma poʻo le RCC).

Sunitinib Malate e faʻaaoga e togafitia ai se kanesa seasea o le manava, manava, poʻo le esophagus ua taʻua gastrointestinal stromal tumo (GIST) ma afai na e inu le vailaʻau imatinib mesylate ma e leʻi taofia le kanesa mai le tuputupu aʻe pe e te le mafai ona imatinib mesylate. Gleevec o se faamauina faʻailoga faʻailoga o le Novartis Fale Faʻafomai Corporation.

Sunitinib Malate e faʻaaogaina e togafitia ai le ituaiga o kanesa o le pancreatic e taʻua o le pancreatic neuroendocrine tumors (pNET) ua alualu i luma ma e le mafai ona togafitia i se taotoga.

 

Faʻafefea Sunitinib Malate Galue?

Sunitinib Malate o se laʻititi-mole mole taofiofia o le tele o receptor tyrosine kinases, o nisi o ia mea o loʻo aʻafia i le tuputupu aʻe, pathologic angiogenesis, ma metastatic alualu i luma o le kanesa. O le sooupu e taofia le faʻatupuina o le tupu-tupu mai o mea tutupu - (PDGFRα ma PDGFRβ), vascular endothelial tuputupu aʻe taliaina (VEGFR1, VEGFR2, ma VEGFR3), sela sela mea faʻaola tali (KIT), FMS-pei tyrosine kinase 3, kolone-faʻaosofia itu vaega ituaiga 1, ma le sela sela sela maua neurotrophic vaega taliaina (RET). Sunitinib Malate taofiofia o gaioiga ma gaioiga o nei receptor tyrosine kinases na faaalia i biochemical ma cellular suʻesuʻe ma sela faateleina o le suʻega. O le muamua metabolite o Sunitinib Malate faʻaalia le malosi e tutusa ma le matua lotoa i biochemical ma sela sela.

O le Sunitinib Malate e taofia le tuʻufaʻatasia o gasegase o le tele o tyrosine kinases (PDGFRβ, VEGFR2, KIT) i le tuma xenografts o loʻo faʻaalia ai le faʻataʻitaʻiga ole tyrosine kinase sini i vivo ma taofia ai le tuputupu aʻe ma le metastasis i nisi o faʻataʻitaʻiga. O le sooupu e taofia le tuputupu aʻe o sela tuma o loʻo faʻaalia ai le faʻatonutonuina o le receptor tyrosine kinases (PDGFR, RET, poʻo le KIT) i le vitro ma le PDGFRβ-ma le VEGFR2-dependant tum angiogenesis in vivo.

 

Sunitinib Malate

 

Faʻafefea Ona Aveina Sunitinib Malate?

Ole fua ole Sunitinib Malate o loʻo faatonuina e lau fomaʻi o le a faʻamoemoeina ile tele o mea. E aofia ai:

❶ le ituaiga ma le faigata o le tulaga o loʻo e faʻaaogaina Sunitinib Malate e togafitia ai

❷ isi faʻafitauli tau fomaʻi e te ono maua

❸ isi vailaʻau o loʻo e inuina

Lau fomaʻi o le a mulimuli ane faatonuina le laʻititi metotia e maua ai le manaʻoga aʻafiaga.

O faʻamatalaga o loʻo mulimuli mai e faʻamatalaina ai ni metotia e masani ona faʻaaogaina pe fautuaina. Peitaʻi, ia mautinoa e te inu inumaga e faʻatonuina e lau fomaʻi. O lau fomaʻi o le a fuafuaina le sili ona lelei metotia e ofi i ou manaʻoga.

 

♦ Vailaau ituaiga ma malosiaga

Sunitinib Malate e sau o se pusa e te foloina. E avanoa i nei malosiaga: 12.5 milligrams (mg), 25 mg, 37.5 mg, ma le 50 mg.

 

♦ Faʻasologa mo kanesa o le manava

O le masani masani o Sunitinib Malate mo gastrointestinal stromal tumors (GISTs) e 50 mg faʻatasi i le aso mo le 4 vaiaso. E sosoʻo mai ma le 2 vaiaso e leai ni vailaʻau. Ma, oe toe fai le taʻamilosaga.

E te ono faʻaauau pea le inuina o le Sunitinib Malate seʻi vagana ua leaga lou kanesa pe e le mafai e lou tino ona faʻataʻitaʻia togafitiga ma le vailaʻau. O le a filifili e lau fomaʻi le taimi e tatau ai ona e tuʻuina le Sunitinib Malate. Mo faʻamatalaga e uiga i le faʻaogaina o le Sunitinib Malate e togafitia ai GIST, vaʻai le fesoʻotaʻiga i lalo.

 

♦ Faʻasologa mo kanesa kanesa

Sunitinib Malate e faʻaaogaina foi e togafitia ai le ituaiga o kanesa o le fatugaʻo e taʻua o le advanced renal cell carcinoma (RCC). O le masani masani o Sunitinib Malate mo le alualu i luma RCC o le 50 mg tasi i le aso mo le 4 vaiaso. E sosoʻo mai ma le 2 vaiaso e leai ni vailaʻau. Ma, oe toe fai le taʻamilosaga.

E te ono faʻaauau pea le inuina o le Sunitinib Malate seʻi vagana ua leaga lou kanesa pe e le mafai e lou tino ona faʻataʻitaʻia togafitiga ma le vailaʻau. O le a filifili e lau fomaʻi le taimi e tatau ai ona e tuʻuina le Sunitinib Malate. Mo nisi faʻamatalaga pe faʻapefea ona faʻaaogaina Sunitinib Malate e togafitia ai le alualu i luma RCC, vaʻai i le fesoʻotaʻiga i lalo.

 

♦ Faʻasologa mo le faʻamalosia togafitiga o le fatu kanesa

Sunitinib Malate o loʻo faʻaaogaina foi o se fesoasoani faʻapitoa mo se ituaiga o kanesa o le fatugaʻo ua taʻua o le RCC i le maeʻa ai o le nephrectomy (o le taʻotoga o le aveʻesea o se fatugaʻo). Le masani metotia o Sunitinib Malate mo lenei faʻaaogaina e 50 mg tasi i le aso mo le 4 vaiaso. E sosoʻo mai ma le 2 vaiaso e leai ni vailaʻau. E masani ona e faʻataʻitaʻia lenei taʻamilosaga iva taimi. Mo auiliiliga pe faʻafefea ona faʻaaogaina Sunitinib Malate o se fofo fesoasoani mo RCC, vaʻai i le fesoʻotaʻiga i lalo.

 

♦ Faʻasologa mo kanesa o le pancreatic

O le masani masani o Sunitinib Malate mo alualu i luma pancreatic neuroendocrine tumors (pNETs) o le 37.5 mg tasi i le aso.

E te ono faʻaauau pea le inuina o le Sunitinib Malate seʻi vagana ua leaga lou kanesa pe e le mafai e lou tino ona faʻataʻitaʻia togafitiga ma le vailaʻau. O le a filifili e lau fomaʻi le taimi e tatau ai ona e tuʻuina le Sunitinib Malate.

 

Manatua: o le metotia sa naʻo faʻamatalaga, faʻamolemole fesoasoani e siaki nisi auiliiliga e lenei 'upega tafaʻilagi:www.fda.gov .

 

 

Faʻafefea Ona Teuina Sunitinib Malate?

Taofi lenei vailaʻau i totonu o le koneteina na sau i totonu, vavalalata, ma mai le aapa atu o tamaiti. Teuina i le vevela o le potu ma alu ese mai le vevela ma le susu (e le o totonu o le faletaele).

E taua le taofi uma o vailaau mai le vaai ma aapa atu i tamaiti le tele o koneteina (e pei o mafaufauga i vaiaso taʻitasi ma i latou e tilotilo mata, kulimi, patches, ma inhalers) e le o tamaiti e puipuia ma e mafai e tamaiti laiti ona tatala faigofie. Mo le puipuia o tamaiti laiti mai le 'ona oona, ia tapuni pea le pulou saogalemu ma vave tuu le vailaau i se nofoaga saogalemu - o se tasi o loʻo agai i luga ma mamao ese mai o latou mata ma aapa atu.

O vailaʻau e le manaʻomia e tatau ona tiaʻi i ni auala faʻapitoa e mautinoa ai e le mafai ona faʻaumatia e fagafao, tamaiti, ma isi tagata. Ae ui i lea, oe le tatau ona fufuluina lenei vailaʻau i lalo o le faletaele. Nai lo lena, o le auala sili e lafoa ai au vailaʻau o le ala i se vailaʻau toe foʻi polokalame. Talanoa i lau fomaʻi faʻafomaʻi pe faʻafesoʻotaʻi lau matagaluega o lapisi / toe faʻataʻitaʻi e iloa ai polokalame e toe ave i tua i lou pitonuʻu Vaʻai le Faʻasaʻolotoina a le FDA o 'Upega Tafaʻilagi upega tafailagi mo nisi faʻamatalaga pe a fai e te le maua se avanoa i se polokalama toe faʻafoʻi.

 

O le a le tele o lo tatou iloa o le itu aʻafiaga o Sunitinib Malate?

Sunitinib Malate leaga faʻalavelave na manatu e ono mafai ona gafatia ma le aʻafiaga o matuia leaga faʻalavelave mea maualalo.

O mea e masani ona tutupu faʻalavelave e fesoʻotaʻi ma Sunitinib Malate togafitiga o le lelava, manava manava, niniva, anorexia, toto maualuga, o le paʻu samasama paʻu, lima-vae paʻu tali atu, ma stomatitis. masani ma Sunitinib Malate nai lo placebo aofia ai manava tata, anorexia, paʻu lanu, mucositis / stomatitis, astenia, suia tofo, ma manava. O manaʻoga faʻaititia na manaʻomia ile 50% o tagata mamaʻi na aʻoaʻoina ile RCC ina ia mafai ai ona faʻatonutonuina le oona o lenei sui.

Matuia (vasega 3 poʻo le 4) ogaoga mea tutupu tutupu i ≤10% o tagata mamaʻi ma aofia ai le toto maualuga, lelava, astenia, manava tatā, ma chemotherapy-faʻaosofia acral erythema. Lab abnormalities fesoʻotaʻi ma Sunitinib Malate togafitiga aofia lipase, amylase, neutrophils, lymphocytes, ma platelets. Hypothyroidism ma feliuaʻi erythrocytosis sa fesoʻotaʻi foʻi ma Sunitinib Malate. O le tele o faʻalavelave e tutupu e mafai ona faʻatautaia e ala ile tausiga lagolago, tui faʻalavelave, poʻo tui faʻaititia.

O se suʻesuʻega talu ai nei na faia i le MD Anderson Cancer Center faʻatusatusa iuga o metastatic renal cell kanesa gasegase na mauaina Sunitinib Malate i luga o le tulaga masani (50 mg / 4 vaiaso i le 2 vaiaso leai) ma i latou na mauaina Sunitinib Malate ma sili atu taimi masani ma pupuu vailaʻau aso malolo. (isi taimi faʻatulagaina). Na vaʻaia o le aotelega o le ola, alualu i luma saoloto ola ma usitaʻia fualaʻau sa sili atu maualuga i tagata mamaʻi na mauaina Sunitinib Malate i luga o le isi taimi faʻatulagaina. O tagata mamaʻi na sili atu lo latou faʻapalepaleina ma maualalo le ogaoga o mea leaga na tutupu e masani ona taitai atu ai i le faʻamutaina o togafitiga o metastatic renal cell cancer cancer.

 

Sunitinib Malate

 

O a isi fualaʻau o le a aʻafia ai le Sunitinib Malate?

Sunitinib Malate e mafai ona mafua ai se faʻafitauli tuga i le fatu. O lou aʻafiaga e ono maualuga atu pe a e faʻaogaina ni isi vailaʻau mo faʻamaʻi, foma, faʻafitauli o le fatu, toto maualuga, faʻaletonu, maʻi o le mafaufau, kanesa, malaria, poʻo le HIV.

O isi taimi e le sefe le faʻaaogaina o vailaʻau i le taimi e tasi. O fualaʻau e mafai ona afaina ai lou toto i le toto o isi vailaʻau e te inuina, e ono faʻateleina ai ni aʻafiaga pe faʻafitia ai le aoga o vailaʻau. Taʻu i lau fomaʻi isi au vailaʻau, aemaise lava

Lenei lisi e le atoa. O isi vailaʻau e ono aʻafia ai le Sunitinib Malate, e aofia ai vailaʻau ma vailaʻau, vailaʻau, ma vailaʻau. E leʻo uma na fesoʻotaʻiga i totonu o fualaʻau.

 

Faʻamaonia e le FDA le Sunitinib Malate As Adjuvant Togafitiga O le sela sela Carcinoma

O Novema 16, 2017, na faʻamaonia ai e le Ofisa o Meaʻai ma Fualaʻau le Sunitinib Malate (Sunitinib Malate, Pfizer Inc.) mo le faʻamalosia o togafitiga o tagata matutua o loʻo i ai le lamatiaga o le toe faia o le sela o le fatu sela peʻa maeʻa nephrectomy.

Faʻamaonia na faʻavae i luga o le tele-ogatotonu, faʻavaomalo, faʻalua-tauaso, placebo-pulea, faʻamasinoga (S-TRAC), i 615 tagata mamaʻi ma maualuga lamatiaga o le toe faia RCC mulimuli ane nephrectomy. Tagata gasegase na faʻasolosolo 1: 1 e mauaina pe 50 mg Sunitinib Malate tasi i aso uma, 4 vaiaso i togafitiga faʻasolosolo e 2 vaiaso toesea, poʻo placebo. Median faamaʻi-leai se ola mo tagata mamaʻi ave Sunitinib Malate o 6.8 tausaga (95% CI: 5.8, e leʻo ausia) faʻatusatusa i 5.6 tausaga (95% CI: 3.8, 6.6) mo tagata mamaʻi mauaina placebo (HR = 0.76; 95% CI: 0.59 , 0.98; p = 0.03). Ile taimi ole suʻesuʻega ole DFS, e leʻi matua le faʻamatalaga ola.

Ole tali masani a le (≥25%) ile Sunitinib Malate ole vaivai / astenia, manava tatā, mucositis / stomatitis, niniva, faaititia le fiaai / anorexia, puaʻi, tiga ole manava, syndrome ole vae-vae, toto maualuga, toto na tupu, faʻasolo ile tofo / tofo suia , dyspepsia, ma le thrombocytopenia. O le igoa o loʻo iai se lapataʻiga ile pusa e lapataʻi ai fomaʻi polofesa ma tagata mamaʻi e uiga ile ono afaina ile hepatoxicity, e ono mafua ai le afaina ole ate pe oti.

O le fualaʻau fautuaina o le Sunitinib Malate mo togafitiga faʻapitoa o le RCC e 50 mg tuʻufaʻatasi taimi i aso uma, pe i ai pe leai ni meaʻai, 4 vaiaso i togafitiga faʻasolosolo e 2 vaiaso malolo mo iva 6-vaiaso taʻamilosaga.

 

Manatua: O loʻo avanoa faʻamatalaga faʻapitoa i le:accessdata.fda.gov  PDF 

 

O fea e mafai ona ou faʻatau ai Sunitinib Malate i luga ole laiga? 

E tele tagata faʻatau / gaosiina le Sunitinib Malate paʻu i le maketi, o le sailia o se tasi e matua taua tele mo tagata uma o loʻo manaʻomia lenei oloa vave. A tatou filifili e faʻatau le Sunitinib Malate paʻu i le maketi, tatou manaʻomia le aʻoaʻo atili faʻamatalaga e uiga i ai, iloa faʻaoga ma ia auala o gaioiga, soʻo se lamatiaga pe a tatou ave Sunitinib Malate paʻu…. I se faʻaopopoga, tau ma lelei e tatau ona avea ma o tatou popolega muamua faʻatauina.

Ina ua maeʻa ona matou suʻesuʻega faʻamaumauga mai maketi, faʻatusatusa i le tele o tagata faʻatau, AASraw foliga mai o ni filifiliga lelei mo na tagata e mananaʻo e faʻatau tele Sunitinib Malate efuefu, o latou gaosiga na puleaina lelei i lalo o le cGMP tulaga, o le lelei mafai ona siakiina i soʻo se taimi ma latou ono tuʻuina uma faʻataʻitaʻiga lipoti pe a e okaina. Ae mo le Sunitinib Malate paʻu tau / tau, e tatau ona talafeagai, i laʻu vaai. Talu ai o loʻo ia te aʻu tau e tele mai kamupani eseese o Sunitinib Malate, faʻatusatusa i le tulaga lelei, ou te manatu o le aasraw o le a le leaga filifiliga.

 

Tusitaiala

[1] Taumafa ma Vailaau Faʻafoeina. Sunitinib (Sutent) Faʻamatalaina faʻamatalaga. 2015

[2] CA Naranjo, U. Busto, ma EM Sellers, "O se metotia mo le fuafuaina o le ono maua i le leaga o vailaʻau faʻasologa," Clinical Pharmacology and Therapeutics, vol. 30, leai. 2, i. 239–245, 1981.

[3] Z. Ansari ma MK George, "O fualaʻau-faʻatosina mai le puipuia-thrombositopenia lona lua i le sunitinib i se tagata maʻi ma le metastatic renal cell carcinoma: o se lipoti lipoti," Journal of Medical Case Reports, vol. 7, mataupu 54, 2013.

[4] K. Sakai, K. Komai, D. Yanase, ma M. Yamada, "Plasma VEGF o se faailoga mo le siakiina ma togafitiga o vasculitic neuropathy," Journal of Neurology, Neurosurgery and Psychiatry, vol. 76, nu. 2, mataupu 296, 2005.

[5] Ofisa o Vailaau a Europa. Sunitinib (SUTENT). Aotelega o Oloa Uiga. 2015

[6] Pajares B, Torres E, Trigo JM et al. Tyrosine kinase taofiofia ma faʻafesoʻotaʻiga o fualaʻau: o se toe iloiloga ma faʻatonuga aoga. Clin Translate Oncol 2012; 14: 94-101.

[7] Teo YL, Ho HK, Chan A. Metabolism-related pharmacokinetic drug-drug interactions with tyrosine kinase inhibitors: malamalamaaga nei, luitau ma fautuaga. Br J Clin Pharmacol 2015; 79: 241-253.

[8] Jamie Dlugosch (2009-03-13). "E faʻasaoina e le biologics ma le Sutent le Pfizer?". Fale teu tupe.

[9] BMJ 31-Jan-2009 "NICE ma le luʻi o vailaʻau o le kanesa" p271

[10] Blay JY, Reichardt P (Iuni 2009). "Advanced gastrointestinal stromal tumo i Europa: o se toe iloiloga o faʻafouga togafitiga faʻutua". Tomai Rev Anticancer Ther. 9 (6): 831–8. faia: 10.1586 / vaitaimi.09.34. PMID 19496720. S2CID 23601578.

0 fiafia
Manatu 73

E mafai ona e fiafia foi

ua tapunia faamatalaga.